Evidence map›Paper›PMID 37773070›Full record

ReviewNature reviews. Neuroscience2023

Excitation-transcription coupling, neuronal gene expression and synaptic plasticity.

Huan Ma, Houda G Khaled, Xiaohan Wang, Nataniel J Mandelberg, Samuel M Cohen, Xingzhi He, Richard W Tsien

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Impact of CaInternational journal of molecular sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. A prelimbic molecular clock of protein synthesis for memory persistence.bioRxiv : the preprint server for biology · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Huan Ma *Department of Neurobiology, Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China. mah@zju.edu.cn.ORCID http://orcid.org/0000-0003-4359-8631
Houda G Khaled *NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0759-0272
Xiaohan Wang *NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7895-2333
Nataniel J Mandelberg *NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9583-8556
Samuel M CohenNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4277-6184
Xingzhi HeDepartment of Neurobiology, Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0009-0000-9776-9665
Richard W TsienNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY, USA. richard.tsien@nyulangone.org.ORCID http://orcid.org/0000-0001-7428-9722
NYU Langone Health · USChinese Academy of Medical Sciences & Peking Union Medical College · CNZhejiang Chinese Medical University · CN

Funding

Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Neuronal Adaptation and Plasticity after Chronic DisuseR01MH071739 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSIEN, RICHARD W · 2015 to 2024
$5.5M
Training Systems and Integrative NeuroscienceT32MH019524 · NIMH · NEW YORK UNIVERSITY · PI KIORPES, LYNNE · 1992 to 2025
$5.2M
NEURONAL FUNCTIONS OF MULTIPLE TYPES OF CALCIUM CHANNELSR01NS024067 · NINDS · YALE UNIVERSITY · PI TSIEN, RICHARD W · 1986 to 2014
$5.0M
Calcium Channels, CaMKII and Mechanisms of Excitation-Transcription CouplingR01NS125271 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2022 to 2026
$2.5M
NHGRI NIH HHS RM1 HG009491NIMH NIH HHS R01 MH071739NIMH NIH HHS T32 MH019524NINDS NIH HHS R01 NS024067NINDS NIH HHS R01 NS125271
6 · The paper itself

Abstract

Excitation-transcription coupling (E-TC) links synaptic and cellular activity to nuclear gene transcription. It is generally accepted that E-TC makes a crucial contribution to learning and memory through its role in underpinning long-lasting synaptic enhancement in late-phase long-term potentiation and has more recently been linked to late-phase long-term depression: both processes require de novo gene transcription, mRNA translation and protein synthesis. E-TC begins with the activation of glutamate-gated N-methyl-D-aspartate-type receptors and voltage-gated L-type Ca

Indexed as

Neuronal PlasticityReceptors, N-Methyl-D-AspartateGene ExpressionHippocampusHumansLong-Term PotentiationNeuronsSynapsesReceptors, N-Methyl-D-Aspartate

Identifiers

PMID37773070
PMCPMC12024187
OpenAlexW4387158015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.