Evidence map›Paper›PMID 37773020›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.

Sarah Hostachy, Huanchen Wang, Guangning Zong, Katy Franke, Andrew M Riley, Peter Schmieder, Barry V L Potter, Stephen B Shears, Dorothea Fiedler

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery.SLAS discovery : advancing life sciences R & D · 2026
    Article
  2. Review
  3. Review
  4. Visualizing and Identifying Inositol Pyrophosphate Isomers in Crystallo.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Article
  6. Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Sarah HostachyLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125, Berlin, Germany.ORCID https://orcid.org/0000-0003-1867-9763
Huanchen WangInositol Signaling Group, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA.
Guangning ZongInositol Signaling Group, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA.
Katy FrankeLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125, Berlin, Germany.
Andrew M RileyMedicinal Chemistry & Drug Discovery Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
Peter SchmiederLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125, Berlin, Germany.ORCID https://orcid.org/0000-0001-9968-9327
Barry V L PotterMedicinal Chemistry & Drug Discovery Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
Stephen B ShearsInositol Signaling Group, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA.
Dorothea FiedlerLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125, Berlin, Germany.ORCID https://orcid.org/0000-0002-0798-946X
Leibniz-Forschungsinstitut für Molekulare Pharmakologie · DENational Institutes of Health · USUniversity of Oxford · GBHumboldt-Universität zu Berlin · DE

Funding

REGULATION OF INOSITOL LIPID SIGNALLING MECHANISMSZ01ES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 1990 to 2008
$4.3M
Intramural NIH HHS Z01 ES080046Swiss National Science Foundation CRSII5_170925Wellcome TrustWellcome Trust 101010
6 · The paper itself

Abstract

Inositol pyrophosphates (PP-IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP-IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo-inositol ring. 5PP-IP

Indexed as

DiphosphatesInositol PhosphatesHalogenationHumansPhosphorylationDiphosphatesInositol Phosphatesfluorineinositol pyrophosphatesphosphoramiditephosphorylationprotein structures

Identifiers

PMID37773020
PMCPMC7615343
OpenAlexW4387157183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.