Evidence map›Paper›PMID 37772934›Full record

ArticleBirth defects research2023

Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Alison K Krajewski, Achal Patel, Christine L Gray, Lynne C Messer, Corinna Y Keeler, Peter H Langlois, Jennita Reefhuis, Suzanne M Gilboa, Martha M Werler, Gary M Shaw and 8 more

Abstract read
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In one paragraph

Article in Birth defects research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alison K KrajewskiUnited States Environmental Protection Agency (U.S. EPA), Office of Research and Development, Center for Public Health & Environmental Assessment, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-1916-5310
Achal PatelDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Christine L GrayDuke Global Health Institute, Durham, North Carolina, USA.
Lynne C MesserOHSU-PSU School of Public Health, Portland, Oregon, USA.
Corinna Y KeelerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Peter H LangloisDepartment of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health-Austin Regional Campus, Austin, Texas, USA.ORCID 0000-0001-6765-4963
Jennita ReefhuisCenters for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Division of Birth Defects and Infant Disorders, Atlanta, Georgia, USA.
Suzanne M GilboaCenters for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Division of Birth Defects and Infant Disorders, Atlanta, Georgia, USA.
Martha M WerlerDepartment of Epidemiology, Boston University, School of Public Health, Boston, Massachusetts, USA.
Gary M ShawStanford University, School of Medicine, Stanford, California, USA.
Suzan L CarmichaelStanford University, School of Medicine, Stanford, California, USA.
Wendy N NembhardDepartment of Epidemiology, University of Arkansas for Medical Sciences, Fay W. Boozman College of Public Health, Little Rock, Arkansas, USA.ORCID 0000-0002-8318-4049
Tabassum Z InsafNew York State Department of Health, Center for Environmental Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York, USA.
Marcia L FeldkampDepartment of Pediatrics, Division of Medical Genetics, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-9171-7848
Kristin M ConwayDepartment of Epidemiology, The University of Iowa, College of Public Health, Iowa City, Iowa, USA.
Danelle T LobdellUnited States Environmental Protection Agency (U.S. EPA), Office of Research and Development, Center for Public Health & Environmental Assessment, Research Triangle Park, North Carolina, USA.
Tania A DesrosiersDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
National Birth Defects Prevention Study

Funding

ACL HHS U01DD001231Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD001032NCBDD CDC HHS U01 DD001037NCBDD CDC HHS U01 DD001224NCBDD CDC HHS U01 DD001226NCBDD CDC HHS U01 DD001227NCBDD CDC HHS U01 DD001231NCBDD CDC HHS U01 DD001300NCBDD CDC HHS U01 DD001302NCBDD CDC HHS U01 DD001304
6 · The paper itself

Abstract

backgroundGastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.

methodsWe used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).

resultsOverall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.

conclusionsFuture work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.

Indexed as

GastroschisisEnvironmental ExposureFemaleHumansInfantMaternal AgeOdds RatioPregnancyPrevalenceenvironmental qualityenvironmental quality indexEQIgastroschisissociodemographic

Identifiers

PMID37772934
PMCPMC10878499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.