ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023
Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- The multi-dimensional spectrum of radiologically isolated syndrome: a systematic review of cognitive and psychosocial evidence.Acta neurologica Belgica · 2026Review
- Health-Related Quality of Life in Radiologically Isolated Syndrome Resembles Relapsing-Remitting Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review.Journal of neurology · 2024Review
- Functional MRI and cognition in multiple sclerosis-Where are we now?Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundRadiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.
objectiveTo examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI).
methodsResting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing.
resultsRIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients' cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus (
conclusionRIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an "incidental finding" but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
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