Evidence map›Paper›PMID 37772175›Full record

ArticleJACS Au2023

DNA-Based Hydrogels with Multidrug Sequential Release for Promoting Diabetic Wound Regeneration.

Wei Li, Hui Xie, Liping Gou, Ye Zhou, Hao Wang, Ruoqing Li, Yong Zhang, Shuyun Liu, Jingping Liu, Yanrong Lu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Wei LiDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
Hui XieCollege of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Liping GouDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
Ye ZhouDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
Hao WangLaboratory of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Ruoqing LiDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
Yong ZhangKey Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0003-0513-8941
Shuyun LiuKey Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Jingping LiuKey Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0001-8364-639X
Yanrong LuKey Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhengliang Eric HeShanghai Soong Ching Ling School, Shanghai 201703, China.
Nan ChenCollege of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.ORCID https://orcid.org/0000-0001-8536-6631
Jiang LiInstitute of Materiobiology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.
Ying ZhuInstitute of Materiobiology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.
Chengshi WangDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
Min LvCollege of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.ORCID https://orcid.org/0000-0003-0587-8528
Sichuan University · CNShanghai Normal University · CNShanghai University · CNChina Soong Ching Ling Foundation · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound (DW) regeneration is highly challenging due to persistent bacterial infection, excessive production of reactive oxygen species (ROS), prolonged inflammatory response, and insufficient angiogenesis. Ideal management requires the integration and sequential release of bactericidal, antioxidative, anti-inflammatory, and angiogenic agents during DW repair. Here, we develop a DNA-based multidrug hydrogel, termed Agilegel, to promote the efficient healing of DW. Hierarchically structured Agilegel can precisely control the sequential release of vascular endothelial growth factor-alpha (VEGF-

Identifiers

PMID37772175
PMCPMC10523493
OpenAlexW4386257202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.