ReviewFrontiers in psychiatry2023
Exercise as an antidepressant: exploring its therapeutic potential.
Review in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects.Molecular genetics and genomics : MGG · 2026Review
- The impact of physical exercise on medical expenditure among middle-aged and older adults: digital literacy as a moderating variable.Frontiers in public health · 2026Article
- Gestational physical exercise prevents early-life behavioral impairments in the offspring of a rat model of attention deficit hyperactivity disorder.Scientific reports · 2025Article
- Diminished Motivation for Voluntary Exercise and Metabolic Dysfunction in Psychiatric Disorders: A Behavioral Perspective on Autism Spectrum Disorder and Depression.International neurourology journal · 2025Article
- Bidirectional relationships between physical exercise and depressive symptoms among Chinese older adults evidence from the China family panel studies.Scientific reports · 2025Article
- Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice.Scientific reports · 2025Article
- The mediating role of life satisfaction in the relationship between physical exercise and depressive symptoms among middle-aged and elderly individuals.Frontiers in public health · 2025Article
- The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions.The journal of physiological sciences : JPS · 2024Article
- The Mediating Role of Interoceptive Sensitivity in the Relationship between Physical Activity and Depression Symptoms in College Students.Behavioral sciences (Basel, Switzerland) · 2024Article
- The Role of Exercise to Improve Physiological, Physical and Psychological Health Outcome in Idiopathic Inflammatory Myopathies (IIM).Journal of inflammation research · 2024Review
- Mood states of active and insufficiently active adolescents related to sleep quality, gender, academic performance and guidelines for the post-COVID-19 scenario.Frontiers in psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has increased the prevalence of depressive disorders worldwide, requiring alternative treatments beyond medication and psychotherapy. Exercise has positive effects on the brain; therefore, it has emerged as a promising therapeutic option for individuals with depression. Considerable research involving humans and animals offers compelling evidence to support the mental health benefits of physical activity or exercise mediated by the regulation of complex theoretical paradigms. However, challenges such as conducting long-term follow-up assessments and considering individual characteristics remain in human studies despite extensive efforts. While animal studies provide valuable insights into the potential benefits of exercise and its impact on outcomes related to depression and anxiety in rodents exposed to different stress paradigms, translating the findings to humans requires careful evaluation. More research is needed to establish precise exercise prescription guidelines and to better understand the complex relationship between exercise and depressive disorders. Therefore, this concise review explores the evidence supporting exercise intervention as an antidepressant treatment and its underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.