Evidence map›Paper›PMID 37771787›Full record

ArticleTheranostics2023

A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to

Kelly Waldeck, Jessica Van Zuylekom, Carleen Cullinane, Twishi Gulati, Kaylene J Simpson, Richard W Tothill, Benjamin Blyth, Rodney J Hicks

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Deciphering the phenotypic responses toEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Targeted Radionuclide Therapy: Current Landscape and Combination Approaches to Improve Oncology Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  5. Article
  6. Article
  7. Science advances · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Identification of 6-Anilino Imidazo[4,5-Journal of medicinal chemistry · 2024
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kelly WaldeckModels of Cancer Translational Research Centre, Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia, 3000.
Jessica Van ZuylekomModels of Cancer Translational Research Centre, Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia, 3000.
Carleen CullinaneModels of Cancer Translational Research Centre, Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia, 3000.
Twishi GulatiSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia, 3010.
Kaylene J SimpsonSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia, 3010.
Richard W TothillSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia, 3010.
Benjamin BlythModels of Cancer Translational Research Centre, Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia, 3000.
Rodney J HicksSt Vincent's Hospital Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia, 3010.
The University of Melbourne · AUSt Vincent's Hospital Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide receptor radionuclide therapy (PRRT) using

Indexed as

LutetiumNeuroendocrine TumorsAnimalsCRISPR-Cas SystemsDNAHeterocyclic Compounds, 1-RingHumansMiceOctreotideRadioisotopes1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidDNAHeterocyclic Compounds, 1-RingLutetiumOctreotideRadioisotopesCRISPRDNA-PKPRRTradionuclide therapysomatostatin receptor

Identifiers

PMID37771787
PMCPMC10526672
OpenAlexW4386263943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.