Evidence map›Paper›PMID 37771754›Full record

ArticleFrontiers in nutrition2023

BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study.

Yiyang Shu, Qi Zhou, Yuting Shao, Hui Lin, Shen Qu, Wenting Han, Xiao Lv, Yanlong Bi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiyang ShuDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Qi ZhouExam Center, School of Medicine, Tongji University, Shanghai, China.
Yuting ShaoDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Hui LinDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shen QuDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Wenting HanDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiao LvDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanlong BiDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The study aimed to determine whether a causal effect exists between body mass index (BMI) or plasma lipid levels and proliferative diabetic retinopathy (PDR) risk in humans. Methods: We utilized univariable (UVMR) and multivariable two-sample Mendelian randomization (MVMR) analyses to confirm the effects of BMI and plasma lipid levels on the risk of PDR. Genetic variants associated with BMI and three plasma lipids were obtained from GWAS summary datasets generated by many different consortia and were deposited in the MR-Base database. The GWAS summary data for PDR from the FinnGen biobank included 2,12,889 participants of European ancestry (8,681 cases and 2,04,208 controls). Inverse variance weighted (IVW) was applied as the main MR analysis. Sensitivity analysis was used to evaluate the robustness of our findings. Results: In the UVMR analysis, the causal associations of genetically predicted BMI with PDR presented a positive association (OR = 1.120, 95% CI = 1.076-1.167, Conclusion: Robust evidence was demonstrated for an independent, causal effect of BMI in increasing the risk of PDR. Further studies are required to understand the potential biological mechanisms underlying this causal relationship.

Indexed as

body mass index (BMI)causal effectdyslipidemiaMendelian randomizationproliferative diabetic retinopathy (PDR)

Identifiers

PMID37771754
PMCPMC10524610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.