Evidence map›Paper›PMID 37771674›Full record

ArticleThe journal of allergy and clinical immunology. Global2023

The SunBEAm birth cohort: Protocol design.

Corinne Keet, Scott H Sicherer, Supinda Bunyavanich, Cynthia Visness, Patricia C Fulkerson, Alkis Togias, Wendy Davidson, Susan Perry, Sanaz Hamrah, Agustin Calatroni and 36 more

Open access · goldAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 19 institutions in 1 country.

Corinne KeetDepartment of Pediatrics, University of North Carolina, Chapel Hill.
Scott H SichererIcahn School of Medicine at Mount Sinai, New York.
Supinda BunyavanichIcahn School of Medicine at Mount Sinai, New York.
Cynthia VisnessRho Inc, Federal Research Operations, Durham.
Patricia C FulkersonDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
Alkis TogiasDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
Wendy DavidsonDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
Susan PerryDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
Sanaz HamrahDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
Agustin CalatroniRho Inc, Federal Research Operations, Durham.
Katina RobinsonRho Inc, Federal Research Operations, Durham.
Lars DunawayRho Inc, Federal Research Operations, Durham.
Carla M DavisDepartment of Pediatrics, Baylor College of Medicine, Houston.
Sara AnvariDepartment of Pediatrics, Baylor College of Medicine, Houston.
Susan M Leong-KeeDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston.
Gurjit Khurana HersheyCincinnati Children's Hospital Medical Center, Cincinnati.
Emily DeFrancoUniversity of Cincinnati, Cincinnati.
Ashley DevonshireCincinnati Children's Hospital Medical Center, Cincinnati.
Haejin KimHenry Ford Health, Detroit.
Christine JosephHenry Ford Health, Detroit.
Brent DavidsonHenry Ford Health, Detroit.
Noel K StrongIcahn School of Medicine at Mount Sinai, New York.
Angela J TsuangIcahn School of Medicine at Mount Sinai, New York.
Marion GroetchIcahn School of Medicine at Mount Sinai, New York.
Julie WangIcahn School of Medicine at Mount Sinai, New York.
Jennifer DantzerDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore.
Kim MuddDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore.
Abimbola AinaDepartment of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore.
Wayne ShrefflerMassachusetts General Hospital, Boston.
Qian YuanMassachusetts General Hospital, Newton-Wellesley Hospital, Newton.
Virginia SimmonsMassachusetts General Hospital, Newton-Wellesley Hospital, Newton.
Donald Y M LeungNational Jewish Health, Denver.
Jessica Hui-BeckmanNational Jewish Health, Denver.
Jania Arcia RamosSaint Joseph Hospital of Obstetrics and Gynecology, Denver.
Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto.
Virginia WinnDivision Maternal Fetal Medicine and Obstetrics, Stanford University, Palo Alto.
Tina SindherSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto.
Stacie M JonesUniversity of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock.
Nirvana A ManningUniversity of Arkansas for Medical Sciences, Little Rock.
Amy M ScurlockUniversity of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock.
Edwin KimDepartment of Pediatrics, University of North Carolina, Chapel Hill.
Alison StuebeDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill.
James E GernDepartment of Pediatrics, University of Wisconsin, Madison.
Anne Marie SinghDepartment of Pediatrics, University of Wisconsin, Madison.
Jennifer KruppMaternal and Fetal Medicine, Obstetrics and Gynecology, SSM Health, Madison.
Robert A WoodDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore.
Icahn School of Medicine at Mount Sinai · USNational Institutes of Health · USJohns Hopkins University · USRho (United States) · USBaylor College of Medicine · USHenry Ford Health System · USUniversity of North Carolina at Chapel Hill · USAllergy, Asthma and Clinical Research Center · USArkansas Children's Hospital · USCincinnati Children's Hospital Medical Center · USNational Jewish Health · USNewton Wellesley Hospital · USUniversity of Wisconsin–Madison · USExempla Saint Joseph Hospital · USMassachusetts General Hospital · USPalo Alto University · USSociety for Maternal-Fetal Medicine · USUniversity of Arkansas for Medical Sciences · USUniversity of Cincinnati · US

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
Treatment of Peanut Allergy with Intradermal Administration of ASP0892 (ARA-LAMP-vax): A Randomized, Double-Blind, Placebo-Controlled, Phase I/II StudyUM2AI130836 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BURKS, A. WESLEY, WILLS-KARP, MARSHA · 2017 to 2023
$62.1M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
New Horizons in the Prevention and Treatment of Food AllergyUM1AI182034 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Supinda Bunyavanich, SCOTT H SICHERER · 2024 to 2026
$40.5M
Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) CohortUM1AI151958 · NIAID · NATIONAL JEWISH HEALTH · PI Donald YM Leung · 2020 to 2026
$38.3M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
RhoFED AA-SCCCU01AI178772 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI Gloria David, Cynthia M Visness · 2023 to 2026
$37.2M
Systems Biology of Early Atopy (SUNBEAM) Analysis and Bioinformatics CenterUM1AI173380 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Supinda Bunyavanich · 2023 to 2026
$10.4M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
University of North Carolina Food Allergy InitiativeUM1AI130936 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM, EDWIN · 2017 to 2023
$2.0M
Evaluating the role of allergen dose and duration in the safety and efficacy of multi-allergen oral immunotherapy with OmalizumabUM1AI130839 · NIAID · STANFORD UNIVERSITY · PI CHINTHRAJAH, R. SHARON · 2017 to 2023
$1.6M
Clinical Research Unit: Johns Hopkins UniversityUM1AI130838 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WOOD, ROBERT A · 2017 to 2023
$1.6M
NCATS NIH HHS KL2 TR001426NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NIAID NIH HHS U01 AI178772NIAID NIH HHS U01 AI181883NIAID NIH HHS U01 AI181962NIAID NIH HHS UM1 AI109565NIAID NIH HHS UM1 AI130570NIAID NIH HHS UM1 AI130780NIAID NIH HHS UM1 AI130781NIAID NIH HHS UM1 AI130838NIAID NIH HHS UM1 AI130839NIAID NIH HHS UM1 AI130934NIAID NIH HHS UM1 AI130936NIAID NIH HHS UM1 AI151958NIAID NIH HHS UM1 AI173380NIAID NIH HHS UM1 AI182034NIAID NIH HHS UM2 AI130836
6 · The paper itself

Abstract

Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.

Indexed as

atopic dermatitisbirth cohorteczemaFood allergymultiomicsomicssystems biology

Identifiers

PMID37771674
PMCPMC10509956
OpenAlexW4379193903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.