ArticleFrontiers in cardiovascular medicine2023
Mean arterial pressure trajectory with premature cardiovascular disease and all-cause mortality in young adults: the Kailuan prospective cohort study.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- The association of high-sensitivity C-reactive protein levels and their changes with heart failure in Chinese diabetes patients.Journal of endocrinological investigation · 2026Article
- Association Between Gestational Blood Pressure Trajectories and Postpartum Normotension Recovery in Hypertensive Disorders: Retrospective Cohort Study.JMIR public health and surveillance · 2026Article
- Effects of a transformative learning theory-based health literacy enhancement program on self-management behaviors and blood pressure in adults with uncontrolled hypertension in Thailand: A cluster randomized controlled trial.Belitung nursing journal · 2026Article
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10 authors at 2 institutions in 1 country.
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Abstract
Background: The association between mean arterial pressure (MAP) trajectory in young adults and risk of cardiovascular diseases (CVD) and all-cause mortality is not well-characterized. The objective of this study was to investigate the effects of different MAP trajectory on the risk of CVD and all-cause mortality among the young. Methods: In the Kailuan cohort study, 19,171 participants aged 18-40 years were enrolled without CVD (including myocardial infarction, stroke, atrial fibrillation and heart failure). The potential hybrid model was used to fit different trajectory patterns according to longitudinal changes of MAP. Hazard ratios and 95% confidence intervals for risk of CVD and all-cause mortality were analyzed using Cox proportional hazard regression models for participants with different trajectories. Results: Five distinct MAP trajectories were identified during 2006-2013. Each of the trajectories was labelled as low-stable, middle-stable, decreasing, increasing, or high-stable. With the low-stable trajectory group as the reference, the multivariate adjusted HR (95%CI) of CVD for the middle-stable, decreasing, increasing and high-stable groups were 2.49 (1.41-4.40), 5.18 (2.66-10.06), 5.91 (2.96-11.80) and 12.68 (6.30-25.51), respectively. The HR (95%CI) for all-cause deaths were 1.27 (0.84-1.94), 2.01 (1.14-3.55), 1.96 (1.04-4.3.72), and 3.28 (1.69-6.37), respectively. Conclusion: In young adults, MAP trajectories were associated with the risk of CVD or all-cause mortality and increasing MAP trajectories within the currently designated "normal" range may still increase the risk for CVD.
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