Evidence map›Paper›PMID 37771100›Full record

ArticleBrain pathology (Zurich, Switzerland)2024

Enhanced Creutzfeldt-Jakob disease surveillance in the older population: Assessment of a protocol for screening brain tissue donations for prion disease.

Alexander H Peden, Adriana Libori, Diane L Ritchie, Helen Yull, Colin Smith, Lovney Kanguru, Anna Molesworth, Richard Knight, Marcelo A Barria

Open access · goldAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alexander H PedenNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Adriana LiboriNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Diane L RitchieNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Helen YullNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Colin SmithNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Lovney KanguruNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Anna MolesworthNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Richard KnightNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Marcelo A BarriaNational CJD Research & Surveillance Unit (NCJDRSU), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-4789-7401
University of Edinburgh · GB

Funding

Department of Health and Social Care and the Scottish GovernmentMedical Research Council MRC G0900580National CJD Research and Surveillance Unit PR-ST-0614-00008_18National CJD Research and Surveillance Unit PR-ST-1214-10002Policy Research Programme
6 · The paper itself

Abstract

Human prion diseases, including Creutzfeldt-Jakob disease (CJD), occur in sporadic, genetic, and acquired forms. Variant Creutzfeldt-Jakob disease (vCJD) first reported in 1996 in the United Kingdom (UK), resulted from contamination of food with bovine spongiform encephalopathy. There is a concern that UK national surveillance mechanisms might miss some CJD cases (including vCJD), particularly in the older population where other neurodegenerative disorders are more prevalent. We developed a highly sensitive protocol for analysing autopsy brain tissue for the misfolded prion protein (PrP

Indexed as

Creutzfeldt-Jakob SyndromePrion DiseasesPrionsTissue and Organ ProcurementAgedAnimalsBrainCattleHumansPrionsbrain bankneurodegenerative diseases, Creutzfeldt-Jakob diseaseprionsurveillancevariant CJD (vCJD)

Identifiers

PMID37771100
PMCPMC10901620
OpenAlexW4387157080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.