ArticleJournal of health, population, and nutrition2023
Dietary total antioxidant capacity is associated with lower disease severity and inflammatory and oxidative stress biomarkers in patients with knee osteoarthritis.
Article in Journal of health, population, and nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Effectiveness of mineral supplements (magnesium, chromium, zinc, selenium, chromium picolinate) in reducing insulin resistance in polycystic ovary syndrome: a meta-analysis of randomized controlled trials.BMC endocrine disorders · 2026Pooled it
- Article
- Article
- Inverse association between dietary antioxidant indices and dietary inflammatory potential in jordanian adults: a cross-sectional study.Journal of health, population, and nutrition · 2026Article
- Dietary Acid Load, Empirical Dietary Inflammatory Index, and Literature-Based Adherence to Mediterranean Diet Score Relationship With Primary Dysmenorrhea.Food science & nutrition · 2026Article
- Toward Personalized ACS Therapy: How Disease Status and Patient Lifestyle Shape the Molecular Signature of Autologous Conditioned Serum.Journal of clinical medicine · 2026Article
- Association Between Nonalcoholic Fatty Liver Disease and the Dietary Index for Gut Microbiota: A Cross-Sectional Study.Food science & nutrition · 2026Article
- Effect of a theory of planned behaviour-based self-care education programme on glycaemic control in patients with diabetic retinopathy: a quasi-experimental study.Journal of nutritional science · 2026Article
- Higher Dietary Phytochemical Index Is Associated With Lower Disease Activity, Inflammation, and Gut Dysbiosis in Patients With Ulcerative Colitis.Food science & nutrition · 2025Article
- Dietary antioxidants and mortality in early-stage CKM syndrome: insights from NHANES.Nutrition & metabolism · 2025Article
- Association between dietary flavonoid intake and anxiety: data from NHANES 2017-2018.BMC public health · 2025Article
- Association of dietary acid load with inflammatory markers, oxidative stress, and clinical features in patients with knee osteoarthritis.Scientific reports · 2025Article
- Osteoarthritis Year in Review 2024: Molecular biomarkers of osteoarthritis.Osteoarthritis and cartilage · 2025Review
- Association between serum vitamin D deficiency and visceral fat indices in adolescents: The Ewha Birth and growth cohort study.PloS one · 2025Article
- Composite dietary antioxidant index and abdominal aortic calcification: a national cross-sectional study.Nutrition journal · 2024Article
- Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database.Journal of health, population, and nutrition · 2024Article
- Dietary and serum antioxidant capacity is inversely associated with patients in osteoarthritis: a case-control study.Journal of health, population, and nutrition · 2024Article
- The association between dietary inflammatory index with some cardio-metabolic risk indices among the patients with type 2 diabetes from Hoveyzeh cohort study: a cross-sectional study.BMC endocrine disorders · 2024Article
- Association between the dietary inflammatory index and all-cause mortality in osteoarthritis.BMC musculoskeletal disorders · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was designed to evaluate the association between dietary total antioxidant capacity and clinical and biochemical variables in patients with osteoarthritis.
methodsThis cross-sectional study was conducted among 160 patients with mild-to-moderate knee osteoarthritis. The Likert version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Index) was used to assess the severity of clinical symptoms in patients with knee osteoarthritis. The secondary outcomes included inflammatory and oxidative stress biomarkers. The participants' usual diets were assessed using a food frequency questionnaire (FFQ), and the dietary total antioxidant capacity (TAC) was calculated based on the ferric reducing antioxidant power method. Additionally, clinical and biochemical variables were evaluated using standard methods.
resultsThe mean age of the participants was 57.2 ± 8.1 years, and 55.6% of them were females. The dietary TAC scores in this study ranged from 3.67 to 24.72, with a mean of 12.05 ± 5.3. We found a significant inverse trend between the dietary TAC score and the total Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score (P = 0.001), as well as the WOMAC stiffness (P = 0.008) and WOMAC physical function scores (P = 0.001). Furthermore, dietary TAC was inversely associated with serum concentrations of interleukin-6 (IL-6) (β = - 0.18, P = 0.020), tumor necrosis factor-α (TNF-α) (β = - 0.67, P < 0.001), matrix metalloproteinase-1 (MMP-1) (β = - 0.33, P < 0.001), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (β = - 0.22, P = 0.005) levels.
conclusionThe results of this study demonstrate an inverse association between dietary total antioxidant capacity and clinical and biochemical variables in patients with osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.