Evidence map›Paper›PMID 37770921›Full record

ArticleBMC chemistry2023

Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents.

Zia Ur Rehman Khan, Nasir Assad, Muhammad Naeem-Ul-Hassan, Muhammad Sher, Fatema Suliman Alatawi, Mohsen Suliman Alatawi, Awatif M E Omran, Rasha M A Jame, Muhammad Adnan, Muhammad Nauman Khan and 6 more

Erratum issuedAbstract read
In one paragraph

Article in BMC chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  10. Review
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  13. Exploring the Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zia Ur Rehman KhanInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Nasir AssadInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Muhammad Naeem-Ul-HassanInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan. sobheel@yahoo.com.
Muhammad SherInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Fatema Suliman AlatawiDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Mohsen Suliman AlatawiDepartment of Pediatrics, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Awatif M E OmranDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Rasha M A JameDepartment of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Muhammad AdnanDepartment of Chemistry, Islamia College Peshawar, Peshawar, 25120, Pakistan.
Muhammad Nauman KhanDepartment of Botany, Islamia College Peshawar, Peshawar, 25120, Pakistan. nomiflora@uop.edu.pk.
Baber AliDepartment of Plant Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Sana WahabDepartment of Plant Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Sarah Abdul RazakInstitute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Muhammad Ammar JavedInstitute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan.
Alevcan KaplanDepartment of Crop and Animal Production, Sason Vocational School, Batman University, 72060, Batman, Turkey.
Mehdi RahimiDepartment of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran. mehdi83ra@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a polar extract of Aconitum lycoctonum L. was used for the synthesis of silver nanoparticles (AgNPs), followed by their characterization using different techniques and evaluation of their potential as antioxidants, amylase inhibitors, anti-inflammatory and antibacterial agents. The formation of AgNPs was detected by a color change, from transparent to dark brown, within 15 min and a surface resonance peak at 460 nm in the UV-visible spectrum. The FTIR spectra confirmed the involvement of various biomolecules in the synthesis of AgNPs. The average diameter of these spherical AgNPs was 67 nm, as shown by the scanning electron micrograph. The inhibition zones showed that the synthesized nanoparticles inhibited the growth of Gram-positive and negative bacteria. FRAP and DPPH assays were used to demonstrate the antioxidant potential of AgNPs. The highest value of FRAP (50.47% AAE/mL) was detected at a concentration of 90 ppm and a DPPH scavenging activity of 69.63% GAE was detected at a concentration of 20 µg/mL of the synthesized AgNPs. 500 µg/mL of the synthesized AgNPs were quite efficient in causing 91.78% denaturation of ovalbumin. The AgNPs mediated by A. lycoctonum also showed an inhibitory effect on α-amylase. Therefore, AgNPs synthesized from A. lycoctonum may serve as potential candidates for antibacterial, antioxidant, anti-inflammatory, and antidiabetic agents.

Indexed as

A. lycoctonumAntibacterialAntidiabeticAnti-inflammatoryAntioxidantSilver nanoparticles

Identifiers

PMID37770921
PMCPMC10540474

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.