Evidence map›Paper›PMID 37770828›Full record

ArticleBMC cancer2023

The effect of sarcopenia and sarcopenic obesity on survival in gastric cancer.

Muzaffer Ece Hakan Şahin, Feray Akbaş, Aytul Hande Yardimci, Eren Şahin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06614699 (Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Short- and Long-term Outcomes in Patients with Colorectal Cancer), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06614699 active not recruitingnot on this map

Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Short- and Long-term Outcomes in Patients with Colorectal Cancer

TypeobservationalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2012 to 2025Enrolled8,000ConditionsColorectal Cancer, Sarcopenia, Obesity and OverweightArmsabdominal fat and muscle area
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

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  11. Observational
  12. The Influence of Muscle Morphology on Oncological Outcomes: A Review.Journal of frailty, sarcopenia and falls · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Muzaffer Ece Hakan ŞahinClinic of Internal Medicine, Ministry of Health Serik State Hospital, 07500, Antalya, Turkey. m.ecehakan@gmail.com.
Feray AkbaşDepartment of Internal Medicine, University of Health Sciences, İstanbul Training and Research Hospital, 34098, Fatih, Istanbul, Turkey.
Aytul Hande YardimciAytul Hande Yardimci, Department of Radiology, University of Health Sciences, Başakşehir Cam and Sakura City Hospital, 34480, Başakşehir, Istanbul, Turkey.
Eren ŞahinFaculty of Medicine, Department of Medical Oncology, Akdeniz University, 07070, Konyaaltı, Antalya, Turkey.
Akdeniz University · TRİstanbul Başakşehir Çam ve Sakura Şehir HastanesiSağlık Bilimleri Üniversitesi · TRSerik Devlet Hastanesi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenic obesity arises from increased muscle catabolism triggered by inflammation and inactivity. Its significance lies in its role in contributing to morbidity and mortality in gastric cancer. This study aims to explore the potential correlation between sarcopenia, sarcopenic obesity, and gastric cancer, as well as their effect on survival. MATERIALS AND

methodsThis retrospective study included 162 patients aged ≥ 18 years who were diagnosed with stomach cancer. Patient age, gender, diagnostic laboratory results, and cancer characteristics were documented. Sarcopenia was assessed using the skeletal muscle index (SMI) (cm2/m2), calculated by measuring muscle mass area from a cross-sectional image at the L3 vertebra level of computed tomography (CT).

resultsAmong the 162 patients, 52.5% exhibited sarcopenia (with cut-off limits of 52.4 cm2/m2 for males and 38.5 cm2/m2 for females), and 4.9% showed sarcopenic obesity. Average skeletal muscle area (SMA) was 146.8 cm2; SMI was 50.6 cm2/m2 in men and 96.9 cm2 and 40.6 cm2/m2 in women, respectively. Sarcopenia significantly reduced mean survival (p = 0.033). There was no association between sarcopenic obesity and mortality (p > 0.05), but mortality was higher in sarcopenic obesity patients (p = 0.041). Patient weight acted as a protective factor against mortality, supporting the obesity paradox. Tumor characteristics, metabolic parameters, and concurrent comorbidities did not significantly impact sarcopenia or mortality.

conclusionSarcopenia is more prevalent in the elderly population and is linked to increased mortality in gastric cancer patients. Paradoxically, higher body mass index (BMI) was associated with improved survival. Computed tomography offers a practical and reliable method for measuring muscle mass and distinguishing these distinctions.

trial registrationThis study was approved by Istanbul Training and Research Hospital Clinical Research Ethics Committee of the University of Health Sciences (29.05.2020/2383).

Indexed as

SarcopeniaStomach NeoplasmsAgedFemaleHumansMaleMuscle, SkeletalObesityRetrospective StudiesBody mass indexComputerized tomographyGastric cancerObesitySarcopeniaSarcopenic obesity,Skeletal muscle index

Identifiers

PMID37770828
PMCPMC10537530
OpenAlexW4387136855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.