Evidence map›Paper›PMID 37770791›Full record

ArticleActa neurologica Belgica2024

Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort.

Jeanette C Reece, Sandra L Neate, Rebekah A Davenport, Elasma Milanzi, Nupur Nag, William Bevens, Maggie Yu, George A Jelinek, Steve Simpson-Yap

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Self-mastery buffers associations between stressful life events and mental quality of life and fatigue in people living with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  3. Connecting the dots: the role of fatigue in female infertility.Reproductive biology and endocrinology : RB&E · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jeanette C ReeceNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0003-2897-0271
Sandra L NeateNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-0761-9848
Rebekah A DavenportMood, Anxiety and Eating Disorders Laboratory, School of Psychological Sciences, The University of Melbourne, Australia.ORCID http://orcid.org/0000-0003-0426-2158
Elasma MilanziCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Australia.ORCID http://orcid.org/0000-0003-1164-2298
Nupur NagNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-0271-0781
William BevensNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0001-6944-6500
Maggie YuNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-2022-4939
George A JelinekNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0001-6157-0910
Steve Simpson-YapNeuroepidemiology Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Level 3, 207 Bouverie St, The University of Melbourne, VIC, 3010, Australia. steve.simpsonyap@unimelb.edu.au.ORCID http://orcid.org/0000-0001-6521-3056
The University of Melbourne · AUThe University of Queensland · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelationships between stressful life events (SLEs) and health outcomes in people living with multiple sclerosis (plwMS), beyond relapse, are not well-established. We examined associations between SLEs and fatigue and symptoms of depression in plwMS.

methods948 participants were queried whether they had experienced any of the 16 SLEs (Holmes-Rahe Social Readjustment Rating Scale) in the preceding 12 months. SLEs were summated to estimate SLE number and SLE load (weighted for the degree of associated stress). Cross-sectional associations between SLE (number, load and individual) and fatigue, and depressive symptoms were examined using log-binomial or log-multinomial regression adjusted for age, sex, relapse symptoms, education, MS type at baseline, disability, fatigue, comorbidity, depression, and antidepressant/antifatigue medications, as appropriate. Sub-analyses restricted to SLEs with a negative emotional impact were performed.

resultsMedian SLE number and load were 2 (IQR 1-2) and 57 (IQR 28-97), respectively. SLE number and load were not associated with a higher prevalence of fatigue, or depressive symptoms, even when restricting analyses to SLEs with a perceived negative emotional impact. A new relationship or family member with a negative impact was associated with a threefold and 2.5-fold higher prevalence of depressive symptoms, respectively. Serious illness was associated with a 28% higher prevalence of depressive symptoms.

conclusionPsychological support for SLEs, and/or intervention targeted to SLE appraisal, may be beneficial in mitigating the adverse effects of SLEs with a perceived negative emotional impact on depressive symptoms in plwMS. Potential associations between serious illness and increased prevalence of depressive symptoms may warrant further investigation.

Indexed as

DepressionMultiple SclerosisCross-Sectional StudiesFatigueHumansLife Change EventsRecurrenceStress, PsychologicalDepressive symptomsFatigueMultiple sclerosisStressful life event

Identifiers

PMID37770791
PMCPMC10965589
OpenAlexW4387127717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.