ArticleNature microbiology2023
Genomic epidemiology reveals multidrug resistant plasmid spread between Vibrio cholerae lineages in Yemen.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 48 citations in OpenAlex.
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- Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13Microbial genomics · 2026Article
- Efficient sequence alignment against millions of prokaryotic genomes with LexicMap.Nature biotechnology · 2026Article
- Genomic analysis of Vibrio cholerae in Western Kenya (2015-2023) reveals persistence of pandemic ST69 and presence of the European-associated ST8 lineage.BMC genomics · 2026Article
- Epidemiological characteristics and outcomes of the 2023-2024 cholera outbreak in South Yemen: a retrospective descriptive study from MSF-supported centres.BMC public health · 2026Article
- Evolution of pandemic cholera at its global source.Nature · 2026Article
- A decade of antimicrobial resistance inMicrobiology spectrum · 2026Article
- The Public Health Burden of Antimicrobial Resistance in Yemen: A Narrative Review.Health science reports · 2026Article
- Multicountry genomic analysis underscores regional cholera spread in Africa.Nature communications · 2026Article
- CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation.Bioinformatics (Oxford, England) · 2026Article
- Genome-wide investigation of outbreak-associatedFrontiers in microbiology · 2026Article
- In-silico identification of anti-cholera phytochemicals from Indian medicinal plants.PloS one · 2026Article
- Genomic characterization of clinical and environmentalFrontiers in microbiology · 2026Article
- Whole Genome Sequencing of Drug-ResistantPathogens (Basel, Switzerland) · 2025Article
- Genomic portrayal of emerging carbapenem-resistant El Tor variantAntimicrobial agents and chemotherapy · 2025Article
- Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Highly drug-resistant Vibrio cholerae harbouring blaPER-7 isolated from travellers returning to England.The Journal of antimicrobial chemotherapy · 2025Article
- Genomic characterization of multidrug-resistant extended-spectrum β-lactamase-producing Vibrio cholerae O1 strains from 2022 cholera outbreak in Kenya.The Journal of antimicrobial chemotherapy · 2025Article
- Recent and convergent reversion to serotype Ogawa in the AFR12 sublineage ofMicrobial genomics · 2025Article
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Authors and funding
20 authors at 8 institutions in 5 countries.
Funding
Abstract
Since 2016, Yemen has been experiencing the largest cholera outbreak in modern history. Multidrug resistance (MDR) emerged among Vibrio cholerae isolates from cholera patients in 2018. Here, to characterize circulating genotypes, we analysed 260 isolates sampled in Yemen between 2018 and 2019. Eighty-four percent of V. cholerae isolates were serogroup O1 belonging to the seventh pandemic El Tor (7PET) lineage, sub-lineage T13, whereas 16% were non-toxigenic, from divergent non-7PET lineages. Treatment of severe cholera with macrolides between 2016 and 2019 coincided with the emergence and dominance of T13 subclones carrying an incompatibility type C (IncC) plasmid harbouring an MDR pseudo-compound transposon. MDR plasmid detection also in endemic non-7PET V. cholerae lineages suggested genetic exchange with 7PET epidemic strains. Stable co-occurrence of the IncC plasmid with the SXT family of integrative and conjugative element in the 7PET background has major implications for cholera control, highlighting the importance of genomic epidemiological surveillance to limit MDR spread.
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