Evidence map›Paper›PMID 37770635›Full record

SynthesisNature genetics2023

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.

Maryam Kavousi, Maxime M Bos, Hanna J Barnes, Christian L Lino Cardenas, Doris Wong, Haojie Lu, Chani J Hodonsky, Lennart P L Landsmeer, Adam W Turner, Minjung Kho and 79 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 5 pooled it
44.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Peripheral Vascular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

89 authors at 20 institutions in 10 countries.

Maryam Kavousi *Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. m.kavousi@erasmusmc.nl.ORCID http://orcid.org/0000-0001-5976-6519
Maxime M Bos *Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Hanna J Barnes *Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Christian L Lino Cardenas *Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5491-4375
Doris Wong *Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Haojie Lu *Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7857-1629
Chani J Hodonsky *Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-8566-5877
Lennart P L Landsmeer *Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Adam W TurnerCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Minjung KhoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Natalie R HasbaniHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Center at Houston, Houston, TX, USA.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Center at Houston, Houston, TX, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Sandesh ChopadeInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
Joris DeelenBiomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-4483-3701
Ernest Diez BenaventeLaboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Edith HoferDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.
Shih-Jen HwangPopulation Sciences, NHLBI/NIH, Framingham, MA, USA.
Sharon M LutzPopulation Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Lotte SlendersCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1942-5845
Maggie A StanislawskiDepartment of Biomedical Informatics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-7768-8868
Jessica van SettenDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4934-7510
Quenna WongDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Lisa R YanekGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Diane M BeckerGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marian BeekmanBiomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0585-6206
Matthew J BudoffThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-9616-1946
Mary F FeitosaDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Chris FinanInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-3319-1937
Austin T HilliardVA Palo Alto Healthcare System, Palo Alto, CA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jason C KovacicVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Brian G KralGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9493-2084
Carl D LangefeldDepartment of Biostatistical Sciences and Data Science, Wake Forest University Health Sciences, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-4266-6949
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Shaista MalikSusan Samueli Integrative Health Institute, Department of Medicine, University of California Irvine, Irvine, CA, USA.
Firdaus A A Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Michal MokryCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-5298-4852
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA.
James G TerryDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeroen van der GrondDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Joyce van MeursDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Rozemarijn VliegenthartDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jianzhao XuDepartment of Biochemistry, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Kendra A YoungDepartment of Epidemiology, University of Colorado, Anschutz Medical Campus, Denver, CO, USA.
Nuno R ZilhãoIcelandic Heart Association, Kopavogur, Iceland.
Robert ZweikerDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria.
Themistocles L AssimesVA Palo Alto Healthcare System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Lewis C BeckerGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel BosDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
J Jeffrey CarrDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4398-8237
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Dominique P V de KleijnDepartment of Vascular Surgery, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Menno de WintherDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences: Atherosclerosis and Ischemic syndromes, Amsterdam Infection and Immunity: Inflammatory diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Hester M den RuijterLaboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Barry I FreedmanDepartment of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0003-0275-5530
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Aroon D HingoraniInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-8365-0081
John E HokansonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Ivana IšgumImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-1869-5034
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-7232-0543
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Leslie A LangeDepartment of Biomedical Informatics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Gerard PasterkampCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-5345-1022
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Helena SchmidtGottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0001-9773-9992
P Eline SlagboomBiomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2875-4723
André G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Meike W VernooijDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0003-1945-7425
Christopher J O'DonnellDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3443-8030
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9717-8459
Rajeev MalhotraCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0120-4630
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6888-1404
Clint L MillerDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA. clintm@virginia.edu.ORCID http://orcid.org/0000-0003-4276-3607
Utrecht University · NLErasmus MC · NLJohns Hopkins University · USUniversity of Michigan · USHarvard University · USLeiden University Medical Center · NLMedical University of Graz · ATThe Lundquist Institute · USUniversity of Virginia · USWake Forest University · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Washington · USBritish Heart Foundation · GBTampere University · FIVA Palo Alto Health Care System · USBoston University · USBrigham and Women's Hospital · USFramingham State University · USIcelandic Heart Association · IS

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2M
The Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0M
Whole-genome sequencing analysis of coronary atherosclerosis and related traitsR01HL146860 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DE VRIES, PAUL STEFAN · 2020 to 2024
$3.9M
Proteomic determinants of direct measures of insulin sensitivityR01DK114183 · NIDDK · STANFORD UNIVERSITY · PI ASSIMES, THEMISTOCLES LEONARD · 2018 to 2022
$3.5M
Toward Diagnostics and Therapies of Molecular Subcategories of CADR01HL125863 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BJORKEGREN, JOHAN M · 2015 to 2018
$3.2M
The Role of Arylsulfatase in Vascular CalcificationR01HL162928 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PAUL STEFAN DE VRIES, Rajeev Malhotra · 2023 to 2026
$2.6M
Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5M
Functional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3M
Genetics of Cardiovascular Disease in Chronic Kidney DiseaseR01HL163972 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA, LI, YUN · 2022 to 2025
$1.9M
Novel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcificationK01HL164687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Christian Lacks Lino Cardenas · 2022 to 2026
$808k
NHLBI NIH HHS F31 HL156463NHLBI NIH HHS K01 HL164687NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL125863NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL146860NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL159514NHLBI NIH HHS R01 HL162928NHLBI NIH HHS R01 HL163972NHLBI NIH HHS R01 HL164577NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK114183
6 · The paper itself

Abstract

Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population. Here we conducted the largest multi-ancestry GWAS meta-analysis of CAC to date, which comprised 26,909 individuals of European ancestry and 8,867 individuals of African ancestry. We identified 11 independent risk loci, of which eight were new for CAC and five had not been reported for CAD. These new CAC loci are related to bone mineralization, phosphate catabolism and hormone metabolic pathways. Several new loci harbor candidate causal genes supported by multiple lines of functional evidence and are regulators of smooth muscle cell-mediated calcification ex vivo and in vitro. Together, these findings help refine the genetic architecture of CAC and extend our understanding of the biological and potential druggable pathways underlying CAC.

Indexed as

AtherosclerosisCoronary Artery DiseaseBlack PeopleEuropean PeopleGenome-Wide Association StudyHumansRisk Factors

Identifiers

PMID37770635
PMCPMC10601987
OpenAlexW4387141392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.