Evidence map›Paper›PMID 37770593›Full record

ArticleScientific reports2023

Ex vivo study of molecular changes of stained teeth following hydrogen peroxide and peroxymonosulfate treatments.

Paulo Wender P Gomes, Simone Zuffa, Anelize Bauermeister, Andrés Mauricio Caraballo-Rodríguez, Haoqi Nina Zhao, Helena Mannochio-Russo, Cajetan Dogo-Isonagie, Om Patel, Paloma Pimenta, Jennifer Gronlund and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Paulo Wender P GomesSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Anelize BauermeisterSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Andrés Mauricio Caraballo-RodríguezSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Haoqi Nina ZhaoSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.
Cajetan Dogo-IsonagieColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Om PatelColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Paloma PimentaColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Jennifer GronlundColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Stacey LavenderColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Shira PilchColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Venda MaloneyColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Michael NorthColgate-Palmolive, Global Technology Center, Piscataway, NJ, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA. pdorrestein@health.ucsd.edu.
Colgate-Palmolive (United States) · USUniversity of California, San Diego · USUniversity of Montana · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White teeth can give confidence and tend to be associated with a healthier lifestyle in modern society. Therefore, tooth-bleaching strategies have been developed, including the use of hydrogen peroxide. Recently, peroxymonosulfate has been introduced as an alternative bleaching method to hydrogen peroxide. Although both chemicals are oxidizing agents, their effects on the molecular composition of the stained teeth are yet unknown. In this study, the molecular profiles of teeth bleached with hydrogen peroxide and peroxymonosulfate were compared using Liquid Chromatography-Tandem Mass Spectrometry. Statistical analyses were used to assess the samples. In addition, reference spectral libraries and in silico tools were used to perform metabolite annotation. Overall, principal component analysis showed a strong separation between control and hydrogen peroxide and peroxymonosulfate samples (p < 0.001). The analysis of molecular changes revealed amino acids and dipeptides in stained teeth samples after hydrogen peroxide and peroxymonosulfate treatments. Noteworthy, the two bleaching methods led to distinct molecular profiles. For example, diterpenoids were more prevalent after peroxymonosulfate treatment, while a greater abundance of alkaloids was detected after hydrogen peroxide treatment. Whereas non-bleached samples (controls) showed mainly lipids. Therefore, this study shows how two different tooth-whitening peroxides could affect the molecular profiles of human teeth.

Indexed as

Tooth BleachingTooth DiscolorationHumansHydrogen PeroxidePeroxidesUreaHydrogen PeroxidePeroxidesperoxymonosulfateUrea

Identifiers

PMID37770593
PMCPMC10539445
OpenAlexW4387129899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.