ArticleNature communications2023
Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Degradable Nanocarriers Capable of Gene Delivery Derived from pH-Responsive Polyester: RROP Copolymerization Between Cyclic Ketene Acetals.Macromolecular rapid communications · 2026Article
- Degradable Vinyl-Based Polymers by Radical Ring-Opening Polymerization: A User Guide.ACS polymers Au · 2026Article
- Molecular Design of Underwater Adhesive Copolymers: Synergy Between Long-Chain Alkyl Crystallization-Melting Switching and Carboxyl Group Interfacial Interactions.Materials (Basel, Switzerland) · 2026Article
- Recent advances onFundamental research · 2026Review
- Catechol Derivative-Based Bioadhesives: Molecular Design for Precision Medical Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Quercetin derived extracellular vesicles combined with ROS responsive hydrogel for diverse damaged tissues repair.Journal of nanobiotechnology · 2026Article
- Multifunctional injectable chitosan-based adhesive enhanced by limited oxidation for assisting bone grafting.Materials today. Bio · 2026Article
- Robust water-activated tissue adhesive patch for arterial/heart wound closure after intervention surgery.Nature communications · 2026Article
- Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality.Advanced healthcare materials · 2026Article
- Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy.Materials today. Bio · 2025Article
- In vivo adhesion fault-tolerant coenzyme/queen bee acid nanomicelles self-crosslinked thermoresponsive adhesive hydrogel for efficient oral ulcer treatment.Bioactive materials · 2025Article
- Reversible biobased adhesives enable closed-loop engineered composites.Nature communications · 2025Article
- Biodegradable Polyesters: Approaches to Increase Degradation Rates for Biomedical Applications.ACS macro letters · 2025Review
- Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair.Nature communications · 2025Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Degradable polymer bone adhesives.Fundamental research · 2025Review
- Recent Progress in Antibacterial Surfaces for Implant Catheters.BME frontiers · 2025Article
- PEG-based polyurethane bioadhesive for wet and adaptable adhesion to circumcision wounds.Regenerative biomaterials · 2025Article
- Wetting-enhanced adhesion of photo-polymerized supramolecular adhesives for both smooth and rough surfaces.Chemical science · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesives with both robust adhesion and tunable degradability are clinically and ecologically vital, but their fabrication remains a formidable challenge. Here we propose an in situ radical ring-opening polymerization (rROP) strategy to design a backbone-degradable robust adhesive (BDRA) in physiological environment. The hydrophobic cyclic ketene acetal and hydrophilic acrylate monomer mixture of the BDRA precursor allows it to effectively wet and penetrate substrates, subsequently forming a deep covalently interpenetrating network with a degradable backbone via redox-initiated in situ rROP. The resulting BDRAs show good adhesion strength on diverse materials and tissues (e.g., wet bone >16 MPa, and porcine skin >150 kPa), higher than that of commercial cyanoacrylate superglue (~4 MPa and 56 kPa). Moreover, the BDRAs have enhanced tunable degradability, mechanical modulus (100 kPa-10 GPa) and setting time (seconds-hours), and have good biocompatibility in vitro and in vivo. This family of BDRAs expands the scope of medical adhesive applications and offers an easy and environmentally friendly approach for engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.