Evidence map›Paper›PMID 37770110›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection.

Alberto Signore, Alvaro A Ordonez, Chanda Arjun, Gurpreet Kaur Aulakh, Nicolas Beziere, Ekaterina Dadachova, Thomas Ebenhan, Ulises Granados, Aruna Korde, Amirreza Jalilian and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Nuclear medicine for the diagnosis of infectious diseases: can we improve?European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Diagnostic Performance of [Journal of clinical medicine · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. DynamicAmerican journal of respiratory and critical care medicine · 2025
    Observational
  8. Article
  9. Article
  10. Automated Production of [Pharmaceutics · 2024
    Article
  11. Review
  12. Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  13. Review
  14. First-in-human infection imaging withFrontiers in nuclear medicine · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 13 countries.

Alberto SignoreNuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome "Sapienza," Rome, Italy.
Alvaro A OrdonezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chanda ArjunRadiopharmaceutical Program, Board of Radiation and Isotope Technology, Mumbai, India.
Gurpreet Kaur AulakhDepartment of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Nicolas BeziereWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Tübingen, Germany.
Ekaterina DadachovaCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Thomas EbenhanNuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa.
Ulises GranadosDepartment of Nuclear Medicine, Hospital Internacional de Colombia-Fundación Cardiovascular de Colombia, Piedecuesta, Colombia.
Aruna KordeDepartment of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Amirreza JalilianDepartment of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Wening LestariNational Nuclear Energy Agency, South Tangerang, Indonesia.
Archana MukherjeeRadiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
Milos PetrikInstitute of Molecular and Translational Medicine and Czech Advanced Technology and Research Institute, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Tamer SakrRadioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt.
Clara L Santos CuevasInstituto Nacional de Investigaciones Nucleares, Ocoyoacac, Mexico.
Mick M WellingInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; and.
Jan Rijn ZeevaartNuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California david.m.wilson@ucsf.edu.
International Atomic Energy Agency · ATJohns Hopkins University · USSouth African Nuclear Energy Corporation (South Africa) · ZAUniversity of Saskatchewan · CABhabha Atomic Research Centre · INEgyptian Atomic Energy Authority · EGFundación Cardiovascular de Colombia · COInstitute of Molecular and Translational Medicine · CZInstituto Nacional de Investigaciones Nucleares · MXLeiden University Medical Center · NLNational Nuclear Energy Agency of Indonesia · IDSapienza University of Rome · ITSiemens (Germany) · DEUniversity of California, San Francisco · US

Funding

Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Sensing living P. aeruginosa using D-alanine derived radiotracersR01EB030897 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., OHLIGER, MICHAEL · 2021 to 2024
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985NIBIB NIH HHS R01 EB030897
6 · The paper itself

Abstract

The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. The meeting focused largely on bacterial pathogens. The group discussed and evaluated the advantages and disadvantages of several radiopharmaceuticals, as well as the science driving various imaging approaches. The main objective was to understand why few infection-targeted radiotracers are used in clinical practice despite the urgent need to better characterize bacterial infections. This article summarizes the resulting consensus, at least among the included scientists and countries, on the current status of radiopharmaceutical development for infection imaging. Also included are opinions and recommendations regarding current research standards in this area. This and future International Atomic Energy Agency-sponsored collaborations will advance the goal of providing the medical community with innovative, practical tools for the specific image-based diagnosis of infection.

Indexed as

Bacterial InfectionsRadiopharmaceuticalsHumansRadiopharmaceuticalsantibioticsdevelopmentinfectionmolecular imagingradiotracer

Identifiers

PMID37770110
PMCPMC10626374
OpenAlexW4387141463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.