Evidence map›Paper›PMID 37770109›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

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Chung Ying Chan, Zijun Chen, Florian Guibbal, Gemma Dias, Gianluca Destro, Edward O'Neill, Mathew Veal, Doreen Lau, Michael Mosley, Thomas C Wilson and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Recent Advances in Targeted Therapies for Adult Gliomas.Current neurology and neuroscience reports · 2026
    Review
  8. EJNMMI radiopharmacy and chemistry · 2026
    Article
  9. Review
  10. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  11. Theranostics in nuclear medicine: the era of precision oncology.Medical oncology (Northwood, London, England) · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Advances in Radioligand Theranostics in Oncology.Molecular diagnosis & therapy · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Chung Ying ChanMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Zijun ChenChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Florian GuibbalMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Gemma DiasMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Gianluca DestroMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Edward O'NeillMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Mathew VealMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Doreen LauMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Michael MosleyMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Thomas C WilsonChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Véronique GouverneurChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Bart CornelissenMRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom; bart.cornelissen@oncology.ox.ac.uk.
CRUK/MRC Oxford Institute for Radiation Oncology · GBUniversity of Oxford · GBScience Oxford · GB

Funding

Cancer Research UK 16466Cancer Research UK 23970Medical Research Council MR/R01695X/1
6 · The paper itself

Abstract

Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme. PARP-targeting compounds radiolabeled with an Auger electron-emitting radionuclide can be trapped close to damaged DNA in tumor tissue, where high ionizing potential and short range lead Auger electrons to kill cancer cells through the creation of complex DNA damage, with minimal damage to surrounding normal tissue. Here, we report on [

Indexed as

AdenocarcinomaPancreatic NeoplasmsAnimalsCell Line, TumorElectronsHumansIodine RadioisotopesMicePoly(ADP-ribose) Polymerase InhibitorsRadiopharmaceuticalsTissue DistributionIodine-123Iodine RadioisotopesPoly(ADP-ribose) Polymerase InhibitorsRadiopharmaceuticals123IAugerPARPradionuclide therapyradiopharmaceuticals

Identifiers

PMID37770109
PMCPMC10690119
OpenAlexW4387141300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.