Evidence map›Paper›PMID 37769662›Full record

ArticleCurrent biology : CB2023

Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.

Serena R Wisner, Aindrila Saha, William N Grimes, Kamila Mizerska, Hannah J Kolarik, Julie Wallin, Jeffrey S Diamond, Raunak Sinha, Mrinalini Hoon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Serena R WisnerDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA.
Aindrila SahaMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA; Cellular and Molecular Biology Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
William N GrimesSynaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Kamila MizerskaDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.
Hannah J KolarikDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA.
Julie WallinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jeffrey S DiamondSynaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Raunak SinhaMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.
Mrinalini HoonDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: mhoon@wisc.edu.
University of Wisconsin–Madison · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USSmith-Kettlewell Eye Research Institute · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
Synaptic Mechanisms in the Mammalian RetinaZ01NS003039 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI DIAMOND, JEFFREY S · 2007 to 2008
$2.8M
Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
Mechanisms regulating formation and maintenance of sensory circuitsR01EY031677 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI HOON, MRINALINI · 2020 to 2024
$1.9M
Intramural NIH HHS Z01 NS003039NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY031677NINDS NIH HHS T32 NS105602
6 · The paper itself

Abstract

Experience regulates synapse formation and function across sensory circuits. How inhibitory synapses in the mammalian retina are sculpted by visual cues remains unclear. By use of a sensory deprivation paradigm, we find that visual cues regulate maturation of two GABA synapse types (GABA

Indexed as

RetinaSensory DeprivationAnimalsgamma-Aminobutyric AcidMammalsPresynaptic TerminalsRetinal Bipolar CellsSynapsesgamma-Aminobutyric AcidGABA receptorinhibitionretinaribbon synapsessensory deprivationsynapse developmentvisual cues

Identifiers

PMID37769662
PMCPMC10615854
OpenAlexW4387107856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.