ArticleCurrent biology : CB2023
A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Fertility reversibly modulatesbioRxiv : the preprint server for biology · 2026Article
- SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.eLife · 2026Article
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- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.Current biology : CB · 2026Article
- Article
- Maternal age modulates progeny social behavior via a small RNA-neuropeptide axis.bioRxiv : the preprint server for biology · 2026Article
- Excitatory GABA receptors shape locomotor circuit organization in C. elegans.Scientific reports · 2026Article
- Feeding decision-making by a single neuron via disparate neurotransmitters.Nature communications · 2026Article
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Context-dependent serotonin signaling links dietary quality to foraging decisions.Nature communications · 2025Article
- Osmolarity regulates Caenorhabditis elegans egg-laying behavior via chemosensory and biophysical mechanisms.The Journal of experimental biology · 2025Article
- Article
- An enteric neuron-expressed variant ionotropic receptor detects ingested salts to regulate salt stress resistance.bioRxiv : the preprint server for biology · 2025Article
- Food sensing controlsScience advances · 2025Article
- Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states.Current opinion in neurobiology · 2025Review
- Fine Adjustment of Caenorhabditis elegans Orientation on Channeled Agar Pads for Imaging Neuroregeneration.Journal of visualized experiments : JoVE · 2025Article
- Review
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Neuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans.Current biology : CB · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Animals generate a wide range of highly coordinated motor outputs, which allows them to execute purposeful behaviors. Individual neurons in the circuits that generate behaviors have a remarkable capacity for flexibility as they exhibit multiple axonal projections, transmitter systems, and modes of neural activity. How these multi-functional properties of neurons enable the generation of adaptive behaviors remains unknown. Here, we show that the HSN neuron in C. elegans evokes multiple motor programs over different timescales to enable a suite of behavioral changes during egg laying. Using HSN activity perturbations and in vivo calcium imaging, we show that HSN acutely increases egg laying and locomotion while also biasing the animals toward low-speed dwelling behavior over minutes. The acute effects of HSN on egg laying and high-speed locomotion are mediated by separate sets of HSN transmitters and different HSN axonal compartments. The long-lasting effects on dwelling are mediated in part by HSN release of serotonin, which is taken up and re-released by NSM, another serotonergic neuron class that directly evokes dwelling. Our results show how the multi-functional properties of a single neuron allow it to induce a coordinated suite of behaviors and also reveal that neurons can borrow serotonin from one another to control behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.