Evidence map›Paper›PMID 37769656›Full record

ArticleCell reports. Medicine2023

AI-clinician collaboration via disagreement prediction: A decision pipeline and retrospective analysis of real-world radiologist-AI interactions.

Morgan Sanchez, Kyle Alford, Viswesh Krishna, Thanh M Huynh, Chanh D T Nguyen, Matthew P Lungren, Steven Q H Truong, Pranav Rajpurkar

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Morgan SanchezDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: morgansanchez@g.harvard.edu.
Kyle AlfordDepartment of Computer Science, Columbia University, New York, NY 10027, USA.
Viswesh KrishnaDepartment of Computer Science, Stanford University, Stanford, CA 94301, USA.
Thanh M HuynhVinBrain JSC, Hanoi 11622, Vietnam.
Chanh D T NguyenVinBrain JSC, Hanoi 11622, Vietnam; VinUniversity, Hanoi 12450, Vietnam.
Matthew P LungrenMicrosoft Corporation, Redmond, WA 98052, USA; University of California San Francisco, San Francisco, CA 94143, USA; Stanford University, Stanford, CA 94301, USA.
Steven Q H TruongVinBrain JSC, Hanoi 11622, Vietnam; VinUniversity, Hanoi 12450, Vietnam.
Pranav RajpurkarDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Funding

RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
NLM NIH HHS T15 LM007092
6 · The paper itself

Abstract

Clinical decision support tools can improve diagnostic performance or reduce variability, but they are also subject to post-deployment underperformance. Although using AI in an assistive setting offsets many concerns with autonomous AI in medicine, systems that present all predictions equivalently fail to protect against key AI safety concerns. We design a decision pipeline that supports the diagnostic model with an ecosystem of models, integrating disagreement prediction, clinical significance categorization, and prediction quality modeling to guide prediction presentation. We characterize disagreement using data from a deployed chest X-ray interpretation aid and compare clinician burden in this proposed pipeline to the diagnostic model in isolation. The average disagreement rate is 6.5%, and the expected burden reduction is 4.8%, even if 5% of disagreements on urgent findings receive a second read. We conclude that, in our production setting, we can adequately balance risk mitigation with clinician burden if disagreement false positives are reduced.

Indexed as

Artificial IntelligenceRadiologistsClinical RelevanceHumansMedicineRetrospective StudiesAI safetyartificial intelligenceclinical decision supportclinician workload estimationcomputer-aided diagnosisdisagreement predictionhuman-AI collaborationmachine learningradiology

Identifiers

PMID37769656
PMCPMC10591030

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.