Evidence map›Paper›PMID 37769125›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Accounting for Competing Events When Evaluating Long-Term Outcomes in Survivors of Critical Illness.

Federico Angriman, Bruno L Ferreyro, Michael O Harhay, Hannah Wunsch, Laura C Rosella, Damon C Scales

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Federico AngrimanDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.ORCID 0000-0003-0971-386X
Bruno L FerreyroInterdepartmental Division of Critical Care Medicine.
Michael O HarhayDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-0553-674X
Hannah WunschDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Laura C RosellaEpidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Damon C ScalesDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Funding

Advancing the design, analysis, and interpretation of acute respiratory distress syndrome trials using modern statistical toolsR01HL168202 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Michael Oscar Harhay, Fan Li · 2023 to 2026
$2.9M
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL141678NHLBI NIH HHS R01 HL168202
6 · The paper itself

Abstract

The clinical trajectory of survivors of critical illness after hospital discharge can be complex and highly unpredictable. Assessing long-term outcomes after critical illness can be challenging because of possible competing events, such as all-cause death during follow-up (which precludes the occurrence of an event of particular interest). In this perspective, we explore challenges and methodological implications of competing events during the assessment of long-term outcomes in survivors of critical illness. In the absence of competing events, researchers evaluating long-term outcomes commonly use the Kaplan-Meier method and the Cox proportional hazards model to analyze time-to-event (survival) data. However, traditional analytical and modeling techniques can yield biased estimates in the presence of competing events. We present different estimands of interest and the use of different analytical approaches, including changes to the outcome of interest, Fine and Gray regression models, cause-specific Cox proportional hazards models, and generalized methods (such as inverse probability weighting). Finally, we provide code and a simulated dataset to exemplify the application of the different analytical strategies in addition to overall reporting recommendations.

Indexed as

Critical IllnessSurvivorsHumansKaplan-Meier EstimateProportional Hazards ModelsRisk AssessmentRisk Factorscompeting eventscritical care survivorsproportional hazards modelresearch designsurvival analysis

Identifiers

PMID37769125
PMCPMC10868356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.