Evidence map›Paper›PMID 37768966›Full record

ArticlePloS one2023

Changes in myocardial blood flow in a canine model of left sided breast cancer radiotherapy.

Oi-Wai Chau, Omar El-Sherif, Matthew Mouawad, Jane M Sykes, John Butler, Heather Biernaski, Robert deKemp, Jennifer Renaud, Gerald Wisenberg, Frank S Prato and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Oi-Wai ChauDepartment of Medical Biophysics, Western University, London, Ontario, Canada.ORCID 0000-0002-1127-4504
Omar El-SherifMayo Clinic, Rochester, Minnesota, United States of America.
Matthew MouawadDepartment of Physics and Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada.
Jane M SykesThames Valley Veterinary Services, London, Ontario, Canada.
John ButlerLawson Health Research Institute, London, Ontario, Canada.
Heather BiernaskiLawson Health Research Institute, London, Ontario, Canada.
Robert deKempNational Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Jennifer RenaudDivision of Cardiology, London Health Sciences Centre, London, Ontario, Canada.
Gerald WisenbergLawson Health Research Institute, London, Ontario, Canada.
Frank S PratoDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Stewart GaedeDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Lawson Health Research Institute · CAWestern University · CACancer Care Ontario · CALondon Health Sciences Centre · CAMayo Clinic · USUniversity of Ottawa · CA

Funding

CIHR 149080
6 · The paper itself

Abstract

backgroundLeft-sided breast cancer patients receiving adjuvant radiotherapy are at risk for coronary artery disease, and/or radiation mediated effects on the microvasculature. Previously our laboratory demonstrated in canines with hybrid 18FDG/PET a progressive global inflammatory response during the initial one year following treatment. In this study, the objective is to evaluate corresponding changes in perfusion, in the same cohort, where resting myocardial blood flow (MBF) was quantitatively measured.

methodIn five canines, Ammonia PET (13NH3) derived MBF was measured at baseline, 1-week, 1, 3, 6 and 12-months after cardiac external beam irradiation. MBF measurements were correlated with concurrent 18FDG uptake. Simultaneously MBF was measured using the dual bolus MRI method.

resultsMBF was significantly increased at all time points, in comparison to baseline, except at 3-months. This was seen globally throughout the entire myocardium independent of the coronary artery territories. MBF showed a modest significant correlation with 18FDG activity for the entire myocardium (r = 0.51, p = 0.005) including the LAD (r = 0.49, p = 0.008) and LCX (r = 0.47, p = 0.013) coronary artery territories.

conclusionIn this canine model of radiotherapy for left-sided breast cancer, resting MBF increases as early as 1-week and persists for up to one year except at 3-months. This pattern is similar to that of 18FDG uptake. A possible interpretation is that the increase in resting MBF is a response to myocardial inflammation.

Indexed as

Breast NeoplasmsMyocardial Perfusion ImagingUnilateral Breast NeoplasmsAnimalsCoronary CirculationDogsFemaleFluorodeoxyglucose F18HeartHumansPositron-Emission TomographyFluorodeoxyglucose F18

Identifiers

PMID37768966
PMCPMC10538714
OpenAlexW4387129772

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.