Evidence map›Paper›PMID 37768545›Full record

ArticleJournal of nephrology2023

The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.

J van der Weijden, P A De Hoogt, M M E Leufkens, A A Keijbeck, H van Goor, M C van den Heuvel, J P M Cleutjens, C Moers, M G Snoeijs, G J Navis and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

J van der WeijdenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box AA53, 9713 GZ, Groningen, The Netherlands. j.van.der.weijden@umcg.nl.ORCID http://orcid.org/0000-0003-0247-7526
P A De HoogtDepartment of Vascular Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-1594-4974
M M E LeufkensDepartment of Pathology, Maastricht University Medical Center+, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.
A A KeijbeckDepartment of Pathology, Maastricht University Medical Center+, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-6332-9477
H van GoorDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-0323-4876
M C van den HeuvelDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-6985-7107
J P M CleutjensDepartment of Pathology, Maastricht University Medical Center+, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-4346-1785
C MoersDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8014-8387
M G SnoeijsDepartment of Vascular Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-4551-2451
G J NavisDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box AA53, 9713 GZ, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-0616-0166
M van LondenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box AA53, 9713 GZ, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-7145-3240
I M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
S P BergerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box AA53, 9713 GZ, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2228-4676
M H De BorstDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box AA53, 9713 GZ, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
C J Peutz-KootstraDepartment of Pathology, Maastricht University Medical Center+, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-0819-0809

Funding

Nierstichting DKF 13A1D303
6 · The paper itself

Abstract

backgroundPeritubular capillary rarefaction plays an important role in the progression of chronic kidney disease. Little is known about the relation between peritubular capillary density, glomerular volume and filtration rate in the healthy kidney.

methodsIn this single-center study, we included 69 living kidney donors who donated between 2005 and 2008 and had representative renal biopsies available. In all donors, glomerular filtration rate was measured using

resultsMean donor age was 52 ± 11 years and mean measured glomerular filtration rate was 119 ± 22 mL/min before donation and 82 ± 15 mL/min at five years after donation. While peritubular capillary density (measured by either number of peritubular capillaries/50,000 μm

conclusionsIn summary, peritubular capillary density was not related to unstimulated kidney function before or after kidney donation, in contrast to glomerular volume. However, number of peritubular capillaries/tubule correlated with the increase in glomerular filtration rate after dopamine stimulation in healthy kidneys, and with glomerular volume. These findings suggest that peritubular capillary density and glomerular volume differentially affect kidney function in healthy living kidney donors.

Indexed as

Kidney TransplantationRenal Insufficiency, ChronicAdultBiopsyCapillariesDopamineGlomerular Filtration RateHumansKidneyLiving DonorsMiddle AgedNephrectomyDopamineGlomerular hypertrophyKidney biopsyKidney functionLiving kidney donationPeritubular capillary rarefaction

Identifiers

PMID37768545
PMCPMC10543576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.