Evidence map›Paper›PMID 37768463›Full record

ArticleBulletin of experimental biology and medicine2023

Individual Features of the Hypothalamic-Pituitary-Thyroid Axis Functioning during Aging in Non-Human Primates.

N D Goncharova, A M Ermolaeva, O A Chigarova, T E Oganyan, L G Ivanova, N V Timoshenko

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

N D GoncharovaLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia. ndgoncharova@mail.ru.
A M ErmolaevaLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia.
O A ChigarovaLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia.
T E OganyanLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia.
L G IvanovaLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia.
N V TimoshenkoLaboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia.
Federal State Budgetary Scientific Institution Research Institute of Medical Primatology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic-pituitary-thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.

Indexed as

AgingHypothalamo-Hypophyseal SystemThyroid GlandAnimalsAnxietyDepressionFemaleMacaca mulattaThyrotropinThyrotropin-Releasing HormoneThyroxineThyrotropinThyrotropin-Releasing HormoneThyroxineaginganxiety-like behaviordepression-like behaviorhypothalamic—pituitary—thyroid axisrhesus monkeys

Identifiers

PMID37768463
OpenAlexW4387115430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.