ArticleJACC. Cardiovascular imaging2024
Body Composition, Coronary Microvascular Dysfunction, and Future Risk of Cardiovascular Events Including Heart Failure.
Article in JACC. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Prognostic Implications of Coronary Microvascular Dysfunction in ST-Elevation Myocardial Infarction by Obesity Status.Diabetes, obesity & metabolism · 2026Observational
- CT Attenuation Map-Derived Body Composition Is Associated with Cardiorespiratory Fitness in Multicenter External Validation.medRxiv : the preprint server for health sciences · 2026Article
- Association of the skeletal muscle mass-to-visceral fat area ratio with cardiovascular disease: a cross-sectional study based on NHANES.Eating and weight disorders : EWD · 2026Article
- Weight-related changes in MRI-derived measures of body composition and liver steatosis: a large-scale analysis for obesity trial design.International journal of obesity (2005) · 2026Article
- Diabetes-related differences in body composition and their prognostic value among patients with heart failure and preserved ejection fraction: a cardiac-MRI-based study.Cardiovascular diabetology · 2026Article
- Association of CT-derived body composition with coronary plaque components and vascular inflammation.The journal of nutrition, health & aging · 2026Article
- Body components at T12/L3 on CT and correlation with survival in esophageal cancer.European radiology · 2026Article
- Association of PREVENT risk model with body fat distribution and subclinical left ventricular dysfunction.American journal of preventive cardiology · 2026Article
- Coronary angiography-derived microcirculatory resistance predicts adverse cardiovascular events in elderly with unstable angina post-percutaneous coronary intervention.Frontiers in aging · 2026Article
- Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies.Frontiers in cardiovascular medicine · 2026Review
- Association of skeletal muscle index and intermuscular adipose tissue index measured by non-contrast chest CT with major adverse cardiovascular events in patients with coronary artery disease: a nested case-control study in a Chinese population.Frontiers in cardiovascular medicine · 2026Article
- Relationship Between Retinal Vascular Measurements and Anthropometric Indices in Patients Diagnosed with Persistent COVID-19.Journal of clinical medicine · 2025Article
- Total-body positron emission tomography: Investigating mechanisms in cardiovascular-kidney-metabolic syndrome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Review
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Vascular function in women with heart failure with preserved ejection fraction: a mismatch beyond diastole.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Enhancing risk stratification in diabetic gastric cancer: muscle-fat ratio from photon-counting CT as a predictor of postoperative complications.BMC medical imaging · 2025Article
- Multimodality Imaging for Diagnosis of Ischemic Heart Disease in Latin American Women from IAEA (International Atomic Energy Agency) Collaboratory.Current cardiology reports · 2025Review
- Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study.European heart journal · 2025Article
- Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBody mass index (BMI) is a controversial marker of cardiovascular prognosis, especially in women. Coronary microvascular dysfunction (CMD) is prevalent in obese patients and a better discriminator of risk than BMI, but its association with body composition is unknown.
objectivesThe authors used a deep learning model for body composition analysis to investigate the relationship between CMD, skeletal muscle (SM), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT), and their contribution to adverse outcomes in patients referred for evaluation of coronary artery disease.
methodsConsecutive patients (n = 400) with normal perfusion and preserved left ventricular ejection fraction on cardiac stress positron emission tomography were followed (median, 6.0 years) for major adverse events, including death and hospitalization for myocardial infarction or heart failure. Coronary flow reserve (CFR) was quantified as stress/rest myocardial blood flow from positron emission tomography. SM, SAT, and VAT cross-sectional areas were extracted from abdominal computed tomography at the third lumbar vertebra using a validated automated algorithm.
resultsMedian age was 63, 71% were female, 50% non-White, and 50% obese. Compared with the nonobese, patients with obesity (BMI: 30.0-68.4 kg/m
conclusionsIn a predominantly female cohort of patients without flow-limiting coronary artery disease, deficient muscularity, not excess adiposity, was independently associated with CMD and future adverse outcomes, especially heart failure. In patients with suspected ischemia and no obstructive coronary artery disease, characterization of lean body mass and coronary microvascular function may help to distinguish obese phenotypes at risk for cardiovascular events.
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