Bone-homing metastatic breast cancer cells impair osteocytes' mechanoresponse in a 3D loading model.

Blayne A Sarazin, Boyuan Liu, Elaine Goldman, Ashlyn N Whitefield, Maureen E Lynch

Open access · goldAbstract read

In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.7field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

Osteocytes in the Metastatic Bone Niche: Mechanistic Pathways and Therapeutic Targets.Pharmaceuticals (Basel, Switzerland) · 2026
Review
Modeling and targeting the hostile physicochemical niche in bone metastasis: from experimental platforms to niche-directed therapy.Frontiers in cell and developmental biology · 2026
Review
Mechanical Loading of Osteocytes via Oscillatory Fluid Flow Regulates Early-Stage PC-3 Prostate Cancer Metastasis to Bone.Advanced biology · 2025
Article
Role of the osteocyte in bone metastasis - The importance of networking.Journal of bone oncology · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Blayne A SarazinDepartment of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.

Boyuan LiuDepartment of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.

Elaine GoldmanDepartment of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.

Ashlyn N WhitefieldDepartment of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.

Maureen E LynchDepartment of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.

University of Colorado Boulder · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer predominantly metastasizes to the skeleton. Mechanical loading is reliably anabolic in bone, and also inhibits bone metastatic tumor formation and bone loss in vivo. To study the underlying mechanisms, we developed a 3D culture model for osteocytes, the primary bone mechanosensor. We verified that MLO-Y4s responded to perfusion by reducing their

Indexed as

3D modelsBone metastasisBreast cancerMechanobiologyOsteocyte

Identifiers

PMID37767467

DOI10.1016/j.heliyon.2023.e20248

PMCPMC10520780

OpenAlexW4386913825

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.