Evidence map›Paper›PMID 37766981›Full record

ArticleiScience2023

Photoswitchable upconversion nanoparticles with excitation-dependent emission for programmed stepwise NIR phototherapy.

Shanshan Zheng, Hengji Zhang, Ting Sheng, Yi Xiang, Jing Wang, Yao Tang, Yihan Wu, Jinliang Liu, Xiaohui Zhu, Yong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shanshan ZhengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Hengji ZhangSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Ting ShengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Yi XiangSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Jing WangSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Yao TangChina Steel Development Research Institute, Beijing 100029, China.
Yihan WuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Jinliang LiuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Xiaohui ZhuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Yong ZhangDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583, Singapore.
Shanghai University · CNChina Iron and Steel Research Institute Group · CNNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmable control over therapeutic processes in phototherapy, like photodynamic therapy (PDT), is promising but challenging. This study uses an energy segmentation-based strategy to synthesize core-multi-shell upconversion nanoparticles (UCNPs), which can release three different colors (red, green, and blue) upon exposure to different near-infrared light (1550 nm, 808 nm, and 980 nm). By combining these UCNPs with photosensitizers and nitric oxide (NO) donors, a smart "off-on" PDT nanoplatform is developed. UCNPs enable independent activation of imaging, release of NO, and generation of reactive oxygen species using specific light wavelengths. The results show that sequential NO release before PDT can greatly alleviate tumor hypoxia by reducing oxygen consumption. This stepwise approach shows potential for precise NIR light-activated and imaging-guided phototherapy.

Indexed as

CancerDrug delivery systemNanoparticlesTherapeutics

Identifiers

PMID37766981
PMCPMC10520541
OpenAlexW4386569896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.