Evidence map›Paper›PMID 37766976›Full record

ArticleiScience2023

Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures.

Masaru Kanekiyo, Rebecca A Gillespie, Morgan Midgett, Katherine J O'Malley, Connor Williams, Syed M Moin, Megan Wallace, Luke Treaster, Kristine Cooper, Hubza Syeda and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Masaru KanekiyoMolecular Engineering Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Rebecca A GillespieMolecular Engineering Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Morgan MidgettCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Katherine J O'MalleyCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Connor WilliamsCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Syed M MoinMolecular Engineering Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Megan WallaceDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Luke TreasterDivision of Cardiothoracic Imaging, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kristine CooperBiostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hubza SyedaMolecular Engineering Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Gwenddolen KettenburgDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Hasala RannuluCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Tabitha SchmerCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Lucia OrtizDepartment of Population Health, University of Georgia, Athens, GA, USA.
Priscila Da Silva CastanhaDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Jacqueline CorryDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Mengying XiaCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Emily OlsenCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel PerezDepartment of Population Health, University of Georgia, Athens, GA, USA.
Gabin YunDivision of Cardiothoracic Imaging, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Barney S GrahamMolecular Engineering Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Simon M Barratt-BoyesDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Douglas S ReedCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USNational Institutes of Health · USUniversity of Georgia · USUniversity of Pittsburgh Medical Center · USUPMC Hillman Cancer Center · US

Funding

NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003I
6 · The paper itself

Abstract

Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model of lethal H5N1 infection in cynomolgus macaques. An inhaled aerosol virus dose of 5.1 log

Indexed as

ImmunologyModel organismVirology

Identifiers

PMID37766976
PMCPMC10520834
OpenAlexW4386484970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.