Evidence map›Paper›PMID 37766342›Full record

ArticleViruses2023

Multi-epitope Antigen for Specific Serological Detection of Dengue Viruses.

Samuel Santos Pereira, Robert Andreata-Santos, Maria Fernanda de Castro-Amarante, Aléxia Adrianne Venceslau-Carvalho, Natiely Silva Sales, Mariângela de Oliveira Silva, Rúbens Prince Dos Santos Alves, Patrícia Jungmann, Luís Carlos de Souza Ferreira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Samuel Santos PereiraLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-9860-224X
Robert Andreata-SantosLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.
Maria Fernanda de Castro-AmaranteLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-2162-9505
Aléxia Adrianne Venceslau-CarvalhoLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.
Natiely Silva SalesLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.
Mariângela de Oliveira SilvaLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-0975-7187
Rúbens Prince Dos Santos AlvesLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-5538-6025
Patrícia JungmannGeneral Pathology, Universidade de Pernambuco, Recife 50100-130, Brazil.
Luís Carlos de Souza FerreiraLaboratory of Vaccine Development, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-4883-1693
Universidade de São Paulo · BRUniversidade de Pernambuco · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 8888130782/2016-00Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.600175/2021-00National Council for Scientific and Technological Development 401506/2020-7São Paulo Research Foundation 2016/20045-7
6 · The paper itself

Abstract

Dengue is an infectious disease of global health concern that continues to require surveillance. Serological testing has been used to investigate dengue-infected patients, but specificity is affected by the co-circulation of ZIKA virus (ZIKV), which shares extensive antigen similarities. The goal of this study was the development of a specific dengue virus (DENV) IgG ELISA based on a multi-epitope NS1-based antigen for antibody detection. The multi-epitope protein (T-ΔNS1), derived from a fragment of the NS1-protein of the four DENV serotypes, was expressed in

Indexed as

Antibodies, ViralAntigens, ViralDengueDengue VirusEpitopesSerologic TestsAnimalsEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMiceSensitivity and SpecificityViral Nonstructural ProteinsZika VirusZika Virus InfectionAntibodies, ViralAntigens, ViralEpitopesImmunoglobulin GViral Nonstructural ProteinsDENVdiagnosisELISANS1 antigenZIKV

Identifiers

PMID37766342
PMCPMC10535193
OpenAlexW4386814654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.