Evidence map›Paper›PMID 37766324›Full record

ArticleViruses2023

Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern.

Ana Medel-Martinez, Cristina Paules, María Peran, Pilar Calvo, Sara Ruiz-Martinez, María Ormazabal Cundin, Alberto Cebollada-Solanas, Mark Strunk, Jon Schoorlemmer, Daniel Oros and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The Effectiveness and Influence of COVID-19 Vaccination on Perinatal Individuals and Their Newborns: An Updated Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ana Medel-MartinezInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.ORCID 0000-0001-5783-4020
Cristina PaulesInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.ORCID 0000-0001-6795-0367
María PeranInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
Pilar CalvoInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
Sara Ruiz-MartinezInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
María Ormazabal CundinInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, Spain.
Alberto Cebollada-SolanasInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, Spain.
Mark StrunkInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, Spain.
Jon SchoorlemmerPlacental Pathophysiology & Fetal Programming Research Group, B46_20R & GIIS-028 del IISA, 50009 Zaragoza, Spain.
Daniel OrosInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
Marta FabreInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.ORCID 0000-0003-4744-0903
Instituto de Salud Carlos III · ESInstituto Aragonés de Ciencias de la Salud · ESHospital Clínico Universitario Lozano Blesa · ESFundacion Agencia Aragonesa para la Investigacion y el Desarrollo · ESInstituto de Investigación Sanitaria Aragón · ES

Funding

FEDER ("Una manera de hacer Europa, Construyendo Europa desde Aragón"/European Social Funds) 277B05_17DGovernment of Aragon (LMP228_21 (2022-2023))
6 · The paper itself

Abstract

The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study of SARS-CoV-2-positive pregnant women between March 2020 and March 2022. The population was divided into pregnancies affected by COVID-19 disease during 2020 (Pre-VOC group) and pregnancies affected after December 2020 by SARS-CoV-2 variants of concern (VOC group). The presence of virus was assessed by RT-PCR, and the viral variant was determined by whole genome sequencing. A total of 104 placentas were examined, among which 54 cases belonged to the Pre-VOC group and 50 cases belonged to the VOC group. Sixteen positive placental RT-PCR tests for SARS-CoV-2 were reported. The NGS analysis confirmed the SARS-CoV-2 lineage in placenta tissue. All samples corresponded to the Pre-VOC group, whereas no placental presence of SARS-CoV-2 was detected in the VOC group (16, 29.6% vs. 0, 0.0%

Indexed as

COVID-19PlacentaPlacenta DiseasesPregnancy Complications, InfectiousSARS-CoV-2AdultFemaleHumansPregnancyProspective StudiesWhole Genome SequencingYoung AdultpregnancySARS-CoV-2SARS-CoV-2 variants of concernwaves of COVID-19

Identifiers

PMID37766324
PMCPMC10536606
OpenAlexW4386749477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.