Evidence map›Paper›PMID 37766295›Full record

ArticleViruses2023

Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy.

Marianna Martinelli, Chiara Giubbi, Maria Letizia Di Meo, Federica Perdoni, Rosario Musumeci, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Clementina Elvezia Cocuzza

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  17. A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marianna MartinelliDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-2273-6986
Chiara GiubbiDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-6112-7572
Maria Letizia Di MeoIRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-3140-4062
Federica PerdoniDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Rosario MusumeciDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-0143-3601
Biagio Eugenio LeoneDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Robert FruscioDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-5688-2194
Fabio LandoniDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-6734-739X
Clementina Elvezia CocuzzaDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-6166-1134
University of Milano-Bicocca · ITAzienda Ospedaliera San Gerardo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the context of cervical cancer prevention, where human papillomavirus (HPV) infection is pivotal, HPV testing is replacing Pap Smear in primary screening. This transition offers an opportunity for integrating self-sampling to enhance coverage. We evaluated the accuracy of HPV testing using self-collected urine and vaginal samples, comparing them to physician-collected cervical swabs. From a cohort of 245 women with abnormal cytology, we collected self-sampled vaginal, urine, and clinician-administered cervical specimens. Employing Anyplex™II HPV28 assay, outcomes revealed HPV positivity rates of 75.1% (cervical), 78.4% (vaginal), and 77.1% (urine). Significant, hr-HPV detection concordance was observed between self-taken cervical samples and clinical counterparts (k = 0.898 for vaginal; k = 0.715 for urine). This study extends beyond accuracy, highlighting self-collected sample efficacy in detecting high-grade cervical lesions. The insight underscores self-sampling's role in bolstering participation and aligns with WHO's goal to eliminate cervical cancer by 2030.

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsAlphapapillomavirusColposcopyFemaleHuman Papillomavirus VirusesHumansPregnancycervical cancerHPV infectionHPV testinglow-risk HPVself-sampling

Identifiers

PMID37766295
PMCPMC10537107
OpenAlexW4386498401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.