Evidence map›Paper›PMID 37766288›Full record

ArticleViruses2023

Low Prevalence of Pre-Treatment and Acquired Drug Resistance to Dolutegravir among Treatment Naïve Individuals Initiating on Tenofovir, Lamivudine and Dolutegravir in Zimbabwe.

Vinie Kouamou, Tendai Washaya, Chiratidzo Ellen Ndhlovu, Justen Manasa

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vinie KouamouUnit of Internal Medicine, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare P.O. Box A178, Zimbabwe.ORCID 0000-0003-3531-7780
Tendai WashayaBiomedical Research and Training Institute, Harare P.O. Box A178, Zimbabwe.
Chiratidzo Ellen NdhlovuUnit of Internal Medicine, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare P.O. Box A178, Zimbabwe.ORCID 0000-0001-7863-7974
Justen ManasaBiomedical Research and Training Institute, Harare P.O. Box A178, Zimbabwe.ORCID 0000-0002-8874-907X
Biomedical Research and Training Institute · ZWUniversity of Zimbabwe · ZW

Funding

Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and PathogenesisD43TW011326 · FIC · BIOMEDICAL RESEARCH & TRAINING INSTITUTE · PI MUNYATI, SHUNGU · 2020 to 2024
$1.6M
FIC NIH HHS D43 TW011326
6 · The paper itself

Abstract

Dolutegravir (DTG) use in combination with tenofovir and lamivudine (TLD) is scaling up in Africa. However, HIV drug resistance (HIVDR) data to DTG remain scarce in Zimbabwe. We assessed the prevalence and genetic mechanisms of DTG resistance in people living with HIV initiating on TLD. A prospective cohort study was conducted between October 2021 and April 2023 among antiretroviral therapy (ART) naïve adults (≥18 years) attending care at an HIV clinic in Zimbabwe. Pre-treatment drug resistance (PDR) was assessed prior to TLD initiation and viral load (VL) outcome and acquired drug resistance (ADR) to TLD were described after 24 weeks follow-up. In total, 172 participants were enrolled in the study. The median (IQR) age and log

Indexed as

LamivudineAdultDolutegravirHumansPrevalenceProspective StudiesTenofovirZimbabweDolutegravirLamivudineTenofovirAfricadolutegravirHIV drug resistancevirological suppressionZimbabwe

Identifiers

PMID37766288
PMCPMC10534864
OpenAlexW4386443668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.