Evidence map›Paper›PMID 37766279›Full record

ArticleViruses2023

DNA Vaccine Co-Expressing Hemagglutinin and IFN-γ Provides Partial Protection to Ferrets against Lethal Challenge with Canine Distemper Virus.

Jianjun Zhao, Yiyang Sun, Ping Sui, Hongjun Pan, Yijun Shi, Jie Chen, Hailing Zhang, Xiaolong Wang, Rongshan Tao, Mengjia Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jianjun ZhaoKey Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.ORCID 0000-0001-9211-1522
Yiyang SunKey Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.ORCID 0000-0001-8272-5483
Ping SuiKey Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Hongjun PanInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences (CAAS), Changchun 130112, China.
Yijun ShiYantai Animal Disease Control Center of Shandong Province, Yantai 264000, China.
Jie ChenInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences (CAAS), Changchun 130112, China.
Hailing ZhangInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences (CAAS), Changchun 130112, China.
Xiaolong WangAgricultural Bureau of Shanyang Country, Shangluo 726400, China.
Rongshan TaoThe Key Laboratory of Environmental Pollution Monitoring and Disease Control, School of Public Health, Guizhou Medical University, Guiyang 550025, China.
Mengjia LiuJinan Customs in Shandong Province of the P.R. of China, Jinan 250000, China.
Dongbo SunKey Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Jiasan ZhengKey Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Heilongjiang Bayi Agricultural University · CNChinese Academy of Agricultural Sciences · CNAgricultural Bank of China · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine distemper (CD), caused by canine distemper virus (CDV), is a highly contagious and lethal disease in domestic and wild carnivores. Although CDV live-attenuated vaccines have reduced the incidence of CD worldwide, low levels of protection are achieved in the presence of maternal antibodies in juvenile animals. Moreover, live-attenuated CDV vaccines may retain residual virulence in highly susceptible species and cause disease. Here, we generated several CDV DNA vaccine candidates based on the biscistronic vector (pIRES) co-expressing virus wild-type or codon-optimized hemagglutinin (H) and nucleocapsid (N) or ferret interferon (IFN)-γ, as a molecular adjuvant, respectively. Apparently, ferret (

Indexed as

DistemperDistemper Virus, CanineVaccines, DNAAnimalsAntibodies, NeutralizingDogsFerretsHemagglutininsInterferon-gammaAntibodies, NeutralizingHemagglutininsInterferon-gammaVaccines, DNAcanine distemper virusDNA vaccineferrethaemagglutininIFN-γ

Identifiers

PMID37766279
PMCPMC10537869
OpenAlexW4386418270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.