Evidence map›Paper›PMID 37766251›Full record

ReviewViruses2023

Immunogenicity and Efficacy of Vaccination in People Living with Human Immunodeficiency Virus.

Eeva Tortellini, Yann Collins Fosso Ngangue, Federica Dominelli, Mariasilvia Guardiani, Carmen Falvino, Fabio Mengoni, Anna Carraro, Raffaella Marocco, Patrizia Pasculli, Claudio Maria Mastroianni and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eeva TortelliniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3110-5193
Yann Collins Fosso NgangueDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Federica DominelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8059-5088
Mariasilvia GuardianiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5874-684X
Carmen FalvinoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Fabio MengoniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Anna CarraroDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7399-5262
Raffaella MaroccoInfectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, 00185 Latina, Italy.
Patrizia PasculliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6678-6865
Claudio Maria MastroianniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1286-467X
Maria Rosa CiardiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Miriam LichtnerInfectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, 00185 Latina, Italy.ORCID 0000-0002-7730-3953
Maria Antonella ZingaropoliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Sapienza University of Rome · ITOspedale Santa Maria Goretti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine should be administered over the lifetime of PLWH are questions that have become clinically relevant. Immune responses to most vaccines are known to be impaired in PLWH. Effective control of viremia with ART and restored CD4+ T-cell count are correlated with an improvement in responsiveness to routine vaccines. However, the presence of immune alterations, comorbidities and co-infections may alter it. In this article, we provide a comprehensive review of the literature on immune responses to different vaccines in the setting of HIV infection, emphasizing the potential effect of HIV-related factors and presence of comorbidities in modulating such responses. A better understanding of these issues will help guide vaccination and prevention strategies for PLWH.

Indexed as

HIV InfectionsImmunogenicity, VaccineVaccinationVaccine EfficacyCoinfectionHumansARTCD4COVID-19HIVHPVimmune responsesinfluenzaPLWHvaccination

Identifiers

PMID37766251
PMCPMC10534440
OpenAlexW4386285312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.