Evidence map›Paper›PMID 37766234›Full record

ArticleViruses2023

Adipose Tissues from Human and Bat-Derived Cell Lines Support Ebola Virus Infection.

Lauren Garnett, Kaylie N Tran, Zachary Schiffman, Kristina A Muise, Quinn E Fletcher, Yvonne A Dzal, Anders Leung, Alix Albietz, Bryce M Warner, Bryan D Griffin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lauren GarnettSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Kaylie N TranSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Zachary SchiffmanSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.ORCID 0000-0003-4778-4941
Kristina A MuiseDepartment of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB R3B 2E9, Canada.ORCID 0000-0002-0497-4086
Quinn E FletcherDepartment of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB R3B 2E9, Canada.ORCID 0000-0002-1755-1605
Yvonne A DzalDepartment of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB R3B 2E9, Canada.
Anders LeungSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Alix AlbietzSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Bryce M WarnerSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Bryan D GriffinSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Darwyn KobasaSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Craig K R WillisDepartment of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB R3B 2E9, Canada.
James E StrongSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.ORCID 0000-0002-0658-6669
Public Health Agency of Canada · CAUniversity of Winnipeg · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ebola virus is a zoonotic pathogen with a geographic range covering diverse ecosystems that are home to many potential reservoir species. Although researchers have detected Ebola virus RNA and serological evidence of previous infection in different rodents and bats, the infectious virus has not been isolated. The field is missing critical knowledge about where the virus is maintained between outbreaks, either because the virus is rarely encountered, overlooked during sampling, and/or requires specific unknown conditions that regulate viral expression. This study assessed adipose tissue as a previously overlooked tissue capable of supporting Ebola virus infection. Adipose tissue is a dynamic endocrine organ helping to regulate and coordinate homeostasis, energy metabolism, and neuroendocrine and immune functions. Through in vitro infection of human and bat (

Indexed as

ChiropteraEbolavirusHemorrhagic Fever, EbolaAdipose TissueAnimalsCell LineEcosystemHumansadipose tissueEbola virusFilovirusesmetabolismreservoir host

Identifiers

PMID37766234
PMCPMC10537186
OpenAlexW4386255764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.