ArticlePolymers2023
Degradation of Poly(ε-caprolactone) Resorbable Multifilament Yarn under Physiological Conditions.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Understanding Polycaprolactone Degradation: Molecular Mechanisms and Implications for Biomedical Device Design.Materials (Basel, Switzerland) · 2026Review
- Prevention of infectious complications in tracheal defects using a biodegradable polylactide patch: an experimental study.General thoracic and cardiovascular surgery · 2026Article
- Multifunctional Electrospun PCL/Starch/n-AlInternational journal of molecular sciences · 2026Article
- Hybrid SES-MEW Scaffold Strategies: A Narrative Review of Multi-Scale Fiber Architectures for Soft and Hard Tissue Engineering.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Review
- Poly(ε-caprolactone) Nanoparticle Tumor-Lysate Vaccination in Mice Generates Hybridoma-Derived Antibodies Enabling Breast Cancer Diagnosis and Chemotherapy Synergy.Biomedicines · 2026Article
- Bone regeneration using adipose derived stem cell spheroids within 3D printed scaffolds in a rabbit radial defect model.Scientific reports · 2025Article
- Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.Bioactive materials · 2025Review
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Electrospun poly(ε-caprolactone)/silver nanoparticle nanofibrous scaffolds with antibacterial activity for wound-dressing applications.RSC advances · 2025Article
- Development and Application of Polymer Scaffolds.Polymers · 2025Article
- Biocompatible Thermoplastics in Additive Manufacturing of Bone Defect Fillers: State-of-the-Art and Future Prospects.Materials (Basel, Switzerland) · 2025Review
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Article
- Iron-Based Metal-Organic Frameworks and Their Polymer Composites for Sustainable Delivery of Herbicides.ACS omega · 2025Article
- Production and Characterization ofPolymers · 2025Article
- Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications.Bioengineering (Basel, Switzerland) · 2025Review
- Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Nonhormonal Contraception.Advances in pharmacological and pharmaceutical sciences · 2025Article
- Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering.International journal of molecular sciences · 2024Article
- Zero-Order Kinetics Release of Lamivudine from Layer-by-Layer Coated Macromolecular Prodrug Particles.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(ε-caprolactone) (PCL) is a hydrophobic, resorbable aliphatic polymer recognized for its low tenacity and extensive elongation at break, making it a popular choice for fabricating biodegradable tissue engineering scaffolds. PCL's slow degradation rate typically results in a complete resorption period of 2 to 3 years. While numerous studies have examined the degradation of PCL in various forms such as films and webs, no study to date has investigated its physiological degradation in multifilament yarn form. In this study, we subjected PCL multifilament yarn samples to physiological conditions in phosphate-buffered saline (PBS) maintained at a consistent temperature of 37 ± 2 °C and agitated at 45 rpm for a period of 32 weeks. We retrieved samples at five different intervals to analyze the degradation profile of the multifilament yarn. This allowed us to estimate the complete resorption time and rate under these in vitro conditions. Over the 32-week period, the multifilament yarn's mass decreased by 4.8%, its elongation at break declined by 42%, the tenacity dropped by 40%, and the peak load at break fell by 46.5%. Based on these findings, we predict that a scaffold structure incorporating PCL multifilament yarn would undergo complete resorption in approximately 14 months under physiological conditions, such as in PBS solution at a pH of approximately 7 and a temperature of 37 °C.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.