Evidence map›Paper›PMID 37765514›Full record

ArticlePolymers2023

Mesoporous Titanium Dioxide Nanoparticles-Poly(N-isopropylacrylamide) Hydrogel Prepared by Electron Beam Irradiation Inhibits the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells.

Huangqin Chen, Yuzhu Hu, Chizhou Wu, Kun Liu, Rui Feng, Mingzhe Yang, Mengyao Zhao, Bin Huang, Yuesheng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Enhancing the Photocatalytic Efficacy of g-CMolecules (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Huangqin ChenDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Yuzhu HuDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Chizhou WuDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Kun LiuHubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, China.
Rui FengDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Mingzhe YangDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Mengyao ZhaoDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Bin HuangDepartment of Stomatology, School of Stomatology and Ophthalmology, Xianing Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Yuesheng LiHubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, China.
Hubei University of Science and Technology · CN

Funding

Provincial College Students Innovation Training Program S202210927030Special Fund for medical research of Hubei University of Science and Technology 2022YKY14the Hubei Provincial Colleges and Universities Outstanding Young and Middle-Aged Technological Innovation Team Project T2020022the Science Development Foundation of Hubei University of Science & Technology 2020TD01, 2021ZX01, 2022FH09Xianning City Key Program of Science & Technology 2021GXYF021
6 · The paper itself

Abstract

An urgently needed approach for the treatment of oral squamous cell carcinoma (OSCC) is the development of novel drug delivery systems that offer targeted specificity and minimal toxic side effects. In this study, we developed an injectable and temperature-sensitive composite hydrogel by combining mesoporous titanium dioxide nanoparticles (MTNs) with Poly(N-isopropylacrylamide) (PNIPAAM) hydrogel to serve as carriers for the model drug Astragalus polysaccharide (APS) using electron beam irradiation. The characteristics of MTNs, including specific surface area and pore size distribution, were analyzed, and the characteristics of MTNs-APS@Hyaluronic acid (HA), such as microscopic morphology, molecular structure, crystal structure, and loading efficiency, were examined. Additionally, the swelling ratio, gel fraction, and microscopic morphology of the composite hydrogel were observed. The in vitro cumulative release curve was plotted to investigate the sustained release of APS in the composite hydrogels. The effects on the proliferation, migration, and mitochondrial membrane potential of CAL-27 cells were evaluated using MTT assay, scratch test, and JC-1 staining. The results indicated successful preparation of MTNs with a specific surface area of 147.059 m

Indexed as

astragalus polysaccharideelectron beam radiationhydrogelmesoporous titanium dioxideoral squamous cell carcinoma

Identifiers

PMID37765514
PMCPMC10535267
OpenAlexW4386443611

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.