Evidence map›Paper›PMID 37765212›Full record

ArticlePharmaceutics2023

M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy.

Jiayi Zhang, Bing Gu, Shimiao Wu, Lin Liu, Ying Gao, Yucen Yao, Degong Yang, Juan Du, Chunrong Yang

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  9. Targeting catalase in cancer.Redox biology · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jiayi ZhangDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Bing GuDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Shimiao WuDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Lin LiuDepartment of Pharmacy, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China.
Ying GaoDepartment of Pharmacy, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China.
Yucen YaoDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Degong YangDepartment of Pharmacy, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China.
Juan DuDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Chunrong YangDepartment of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
Jiamusi University · CNShantou University Medical College · CNShantou University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515110476Heilongjiang Administration of Traditional Chinese Medicine NO. ZHY18-161National Science Foundation of China 82273881 and 81874305Open Fund of Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Im-munopathology GDKL202214SUMC Scientific Research Initiation Grant 510858046 and 510858056
6 · The paper itself

Abstract

Tumor hypoxia is considered one of the key causes of the ineffectiveness of various strategies for cancer treatment, and the non-specific effects of chemotherapy drugs on tumor treatment often lead to systemic toxicity. Thus, we designed M1 macrophage-biomimetic-targeted nanoparticles (DOX/CAT@PLGA-M1) which contain oxygen self-supplied enzyme (catalase, CAT) and chemo-therapeutic drug (doxorubicin, DOX). The particle size of DOX/CAT@PLGA-M1 was 202.32 ± 2.27 nm (

Indexed as

cancer treatmentcatalaseM1 macrophagetumor hypoxiatumor microenvironment

Identifiers

PMID37765212
PMCPMC10534656
OpenAlexW4386284981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.