ArticlePharmaceutics2023
Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial.
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Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Serum concentrations of selective serotonin reuptake inhibitors and atypical antipsychotics in children and adolescents: data from routine clinical care.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Bridging Literature and Real-World Evidence: External Evaluation and Development of Fluoxetine Population Pharmacokinetics Model.Pharmaceutics · 2025Article
- Sex-Specific Differences in Antidepressant and Antipsychotic Treatment Outcomes and Serum Levels in Children and Adolescents.Pharmaceutics · 2025Article
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Authors and funding
33 authors at 17 institutions in 4 countries.
Michael FreyFaculty of Applied Healthcare Science, Deggendorf Institute of Technology, 94469 Deggendorf, Germany.ORCID 0000-0001-5824-6757
Lukasz SmigielskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zürich, Switzerland.
Elvira TiniDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zürich, Switzerland.
Stefanie FeketeDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Christian FleischhakerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Freiburg, 79104 Freiburg, Germany.
Christoph WewetzerKIRINUS Tagesklinik Kinder und Jugendliche, 80639 Munich, Germany.
Andreas KarwautzDepartment of Child and Adolescent Psychiatry, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9053-998X
Christoph U CorrellDepartment of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-7254-5646
Manfred GerlachDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Regina TaurinesDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Paul L PlenerDepartment of Child and Adolescent Psychiatry, Medical University Vienna, 1090 Vienna, Austria.
Uwe MalzahnClinical Trial Center Wuerzburg, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Selina KornbichlerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, 80097 Munich, Germany.
Laura WeningerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, 80097 Munich, Germany.
Matthias BrockhausMax-Planck-Institut für Psychiatry, 80804 Munich, Germany.
Su-Yin Reuter-DangSpecialist Practice and Medical Care Centre for Child and Adolescent Psychiatry Munich, Dr. Epple & Dr. Reuter-Dang, 81241 Munich, Germany.
Karl ReitzleSpecialist Practice and Medical Care Center for Child and Adolescent Psychiatry Munich, 81241 Munich, Germany.
Hans RockCentral Information Office, Department of Neurology, Philipps University of Marburg, 35112 Marburg, Germany.
Hartmut ImgartParkland-Clinic, Clinic for Psychosomatics and Psychotherapy, Academic Teaching Hospital for the University Gießen, 34537 Bad Wildungen, Germany.
Peter HeuschmannClinical Trial Center Wuerzburg, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-2681-3515
Stefan UntereckerDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Wolfgang BriegelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-8253-5070
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.ORCID 0000-0003-4595-1144
Jörg M FegertDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Hospital Ulm, 89075 Ulm, Germany.
Tobias HellenschmidtDepartment of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic medicine, Vivantes Clinic Berlin Neukölln, 12351 Berlin, Germany.
Michael KaessClinic for Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, 69115 Heidelberg, Germany.
Michael KölchDepartment of Child and Adolescent Psychiatry and Psychotherapy, Brandenburg Medical School Brandenburg, 16816 Neuruppin, Germany.ORCID 0000-0003-2878-5121
Tobias RennerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Psychiatry and Psychotherapy Tuebingen, Center of Mental Health Tuebingen, 72076 Tuebingen , Germany.
Christian RexrothClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg at the Regensburg District Hospital, Medbo KU, 93053 Regensburg, Germany.ORCID 0009-0007-4562-0894
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zürich, Switzerland.
Gerd Schulte-KörneDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, 80097 Munich, Germany.
Marcel RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0001-7628-8299
Karin Maria EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-0270-0954
LMU Klinikum · DEUniversity of Zurich · CHGerman Center for Pediatric and Adolescent Rheumatology · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Ulm · DEHeidelberg University · DELeopoldina Krankenhaus Schweinfurt · DEMax Planck Institute of Psychiatry · DEMedical University of Vienna · ATMedizinische Hochschule Brandenburg Theodor Fontane · DENorthwell Health · USPhilipps University of Marburg · DEUniversity Medical Center Freiburg · DEUniversity of Bern · CHUniversity of Regensburg · DEUniversity of Würzburg · DEVivantes Klinikum · DE
Funding
Federal Institute for Drugs and Medical Devices V-15322/68605/2013-2018Federal Ministry of Education and Research 001EZ0937
Abstract
Fluoxetine is the recommended first-line antidepressant in many therapeutic guidelines for children and adolescents. However, little is known about the relationships between drug dose and serum level as well as the therapeutic serum reference range in this age group. Within a large naturalistic observational prospective multicenter clinical trial ("TDM-VIGIL"), a transdiagnostic sample of children and adolescents (
Indexed as
adolescentsantidepressantsdepressionpharmacovigilancereference rangeselective serotonin reuptake inhibitorssteady-state concentrationTDM
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.