Evidence map›Paper›PMID 37765042›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Neuroprotective Properties of Oleanolic Acid-Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments.

Katarzyna Stępnik, Wirginia Kukula-Koch, Wojciech Plazinski, Magda Rybicka, Kinga Gawel

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katarzyna StępnikDepartment of Physical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Pl. M. Curie-Skłodowskiej 3, 20-031 Lublin, Poland.ORCID 0000-0002-9812-9114
Wirginia Kukula-KochDepartment of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, ul. Chodzki 1, 20-093 Lublin, Poland.ORCID 0000-0001-7076-600X
Wojciech PlazinskiDepartment of Biopharmacy, Medical University of Lublin, ul. Chodzki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-1427-8188
Magda RybickaDepartment of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, ul. Abrahama 58, 80-307 Gdańsk, Poland.ORCID 0000-0003-3768-3514
Kinga GawelDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, ul. Jaczewskiego Str. 8b, 20-090 Lublin, Poland.ORCID 0000-0001-8857-847X
Medical University of Lublin · PLGdańsk Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oleanolic acid (OA), as a ubiquitous compound in the plant kingdom, is studied for both its neuroprotective and neurotoxic properties. The mechanism of acetylcholinesterase (AChE) inhibitory potential of OA is investigated using molecular dynamic simulations (MD) and docking as well as biomimetic tests. Moreover, the in vitro SH-SY5Y human neuroblastoma cells and the in vivo zebrafish model were used. The inhibitory potential towards the AChE enzyme is examined using the TLC-bioautography assay (the IC

Indexed as

acetylcholinesterasemolecular dockingmolecular dynamic simulationsneuroprotectionzebrafish

Identifiers

PMID37765042
PMCPMC10536188
OpenAlexW4386325775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.