Evidence map›Paper›PMID 37764983›Full record

ArticlePathogens (Basel, Switzerland)2023

The Efficiency of TB LAM Antigen Test to Xpert MTB/RIF Ultra Test for the Diagnosis of Tuberculous Pericarditis Using Pericardial Fluid Samples.

Samuel Alomatu, Sandeep Vasaikar, Kandathil Thomas, Thozama Dubula, Khulile Moeketsi

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Samuel AlomatuCardiology Unit, Department of Internal Medicine, Nelson Mandela Central Hospital, Walter Sisulu University, Mthatha 5117, South Africa.ORCID 0000-0002-1587-7038
Sandeep VasaikarDepartment of Microbiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa.ORCID 0000-0001-7859-1320
Kandathil ThomasCardiology Unit, Department of Internal Medicine, Nelson Mandela Central Hospital, Walter Sisulu University, Mthatha 5117, South Africa.
Thozama DubulaOffice of Dean, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5117, South Africa.
Khulile MoeketsiCardiology Unit, Department of Internal Medicine, Nelson Mandela Central Hospital, Walter Sisulu University, Mthatha 5117, South Africa.
Nelson Mandela Academic Hospital · ZAWalter Sisulu University · ZA

Funding

Walter Sisulu University Internal Medicine
6 · The paper itself

Abstract

Medical considerations for early diagnosis of tuberculous pericarditis (TBP) include Xpert MTB/RIF Ultra and TB lipoarabinomannan (LAM) antigen (Ag) tests, with immunological status influencing the performance of the latter. An evaluation of the efficiency of Xpert MTB/RIF Ultra and TB LAM Ag in detecting TBP was conducted using pericardial fluid samples from 46 patients with suspected TBP. Fifteen patients (34.1%) were diagnosed with TBP according to culture results. TB LAM Ag's sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 33.3%, 100%, 100%, 74.4%, 0, and 0.67, respectively. The sensitivity, specificity, PLR, NLR, PPV, and NPV of Xpert MTB/RIF Ultra were 80%, 93.1%, 11.6, 0.21, 85.7%, and 90%, respectively. There was an association observed between a positive TB LAM Ag test and HIV status. When compared to the Xpert MTB/RIF Ultra test, TB LAM Ag has lower accuracy for the detection of microbiologically proven tuberculous pericarditis, yet its usage in HIV-positive populations may be worth exploring. The TB LAM Ag assay is not the best first-line test for the diagnosis of tuberculous pericarditis, and it should be used in conjunction with other diagnostic tests.

Indexed as

Antigens, BacterialLipopolysaccharidesMycobacterium tuberculosisPericardial FluidPericarditis, TuberculousAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsSensitivity and SpecificityAntigens, BacteriallipoarabinomannanLipopolysaccharidesdiagnosisextrapulmonary tuberculosispericardial fluidTB LAM Agtuberculous pericarditisXpert MTB/RIF Ultra

Identifiers

PMID37764983
PMCPMC10536891
OpenAlexW4386894242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.