Evidence map›Paper›PMID 37764957›Full record

ReviewPathogens (Basel, Switzerland)2023

Exploring the Potential of Fecal Microbiota Transplantation as a Therapy in Tuberculosis and Inflammatory Bowel Disease.

Adrian Boicean, Dan Bratu, Sorin Radu Fleaca, Gligor Vasile, Leeb Shelly, Sabrina Birsan, Ciprian Bacila, Adrian Hasegan

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  9. The Gut-Kidney Axis in Chronic Kidney Diseases.Diagnostics (Basel, Switzerland) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Adrian BoiceanFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Dan BratuFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0000-0001-8612-6293
Sorin Radu FleacaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0000-0002-2444-9828
Gligor VasileCounty Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania.
Leeb ShellyCounty Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania.
Sabrina BirsanFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0009-0007-7368-7674
Ciprian BacilaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0000-0002-0029-7591
Adrian HaseganFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Lucian Blaga University of Sibiu · RO

Funding

Ministerul Cercetării și Inovării contract no. 28PFE/30.12.2021
6 · The paper itself

Abstract

This review explores the potential benefits of fecal microbiota transplantation (FMT) as an adjunct treatment in tuberculosis (TB), drawing parallels from its efficacy in inflammatory bowel disease (IBD). FMT has shown promise in restoring the gut microbial balance and modulating immune responses in IBD patients. Considering the similarities in immunomodulation and dysbiosis between IBD and TB, this review hypothesizes that FMT may offer therapeutic benefits as an adjunct therapy in TB. Methods: We conducted a systematic review of the existing literature on FMT in IBD and TB, highlighting the mechanisms and potential implications of FMT in the therapeutic management of both conditions. The findings contribute to understanding FMT's potential role in TB treatment and underscore the necessity for future research in this direction to fully leverage its clinical applications. Conclusion: The integration of FMT into the comprehensive management of TB could potentially enhance treatment outcomes, reduce drug resistance, and mitigate the side effects of conventional therapies. Future research endeavors should focus on well-designed clinical trials to develop guidelines concerning the safety and short- and long-term benefits of FMT in TB patients, as well as to assess potential risks.

Indexed as

adjunct therapydysbiosisfecal microbiota transplantationFMTgut microbiotaIBDimmunomodulationinflammatory bowel diseaseTBtuberculosis

Identifiers

PMID37764957
PMCPMC10535282
OpenAlexW4386601661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.