Evidence map›Paper›PMID 37764869›Full record

ArticleNutrients2023

A Large Genetic Causal Analysis of the Gut Microbiota and Urological Cancers: A Bidirectional Mendelian Randomization Study.

Zhaofa Yin, Bohan Liu, Shijian Feng, Yushi He, Cai Tang, Pengan Chen, Xinyi Wang, Kunjie Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhaofa YinDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Bohan LiuDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Shijian FengDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Yushi HeDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Cai TangDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Pengan ChenDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Xinyi WangDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Kunjie WangDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.ORCID 0000-0001-8289-2791
Sichuan University · CN

Funding

West China Hospital of Sichuan University 2020HXBH149West China Hospital of Sichuan University Z2021JC004
6 · The paper itself

Abstract

backgroundSeveral observational studies and clinical trials have shown that the gut microbiota is associated with urological cancers. However, the causal relationship between gut microbiota and urological cancers remains to be elucidated due to many confounding factors.

methodsIn this study, we used two thresholds to identify gut microbiota GWAS from the MiBioGen consortium and obtained data for five urological cancers from the UK biobank and Finngen consortium, respectively. We then performed a two-sample Mendelian randomization (MR) analysis with Wald ratio or inverse variance weighted as the main method. We also performed comprehensive sensitivity analyses to verify the robustness of the results. In addition, we performed a reverse MR analysis to examine the direction of causality.

resultsOur study found that family

conclusionsOur study confirms the role of specific gut microbial taxa on urological cancers, explores the mechanism of gut microbiota on urological cancers from a macroscopic level, provides potential targets for the screening and treatment of urological cancers, and is dedicated to providing new ideas for clinical research.

Indexed as

Gastrointestinal MicrobiomeKidney NeoplasmsLactobacillalesTesticular NeoplasmsUrologic NeoplasmsBacteroidetesClostridiaceaeEubacterialesEubacteriumGenome-Wide Association StudyHumansMaleMendelian Randomization Analysisgeneticsgut microbiotamendelian randomizationurological cancer

Identifiers

PMID37764869
PMCPMC10537765
OpenAlexW4386912864

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.