Evidence map›Paper›PMID 37764833›Full record

ArticleNutrients2023

Erythritol Can Inhibit the Expression of Senescence Molecules in Mouse Gingival Tissues and Human Gingival Fibroblasts.

Haruna Yokoi, Masae Furukawa, Jingshu Wang, Yu Aoki, Resmi Raju, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Haruna YokoiDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Masae FurukawaDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.ORCID 0000-0001-5674-0671
Jingshu WangDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Yu AokiResearch Department, Daiichi Sankyo Healthcare Co., Ltd., Tokyo 140-8710, Japan.
Resmi RajuDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Yoriko IkuyoDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Mitsuyoshi YamadaDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Yosuke ShikamaDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Kenji MatsushitaDepartment of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.ORCID 0000-0003-2402-8633
National Center for Geriatrics and Gerontology · JPKyushu University · JPTohoku University · JPAichi Gakuin University · JPDaiichi-Sankyo (Japan) · JP

Funding

Hokuto Foundation for Bioscience R1 No. 19Japan Society for the Promotion of Science RPD No. 21J40002, 22KJ3207KAKENHI Grant No. 22K10112, 20H03904 and 23H03122the National Geriatrics and Gerontology of Japan Grant No. 20-13, 21-6
6 · The paper itself

Abstract

Oral aging causes conditions including periodontal disease. We investigated how the sugar alcohol erythritol, which has anti-caries effects, impacts aging periodontal tissues and gingival fibroblasts in mice and humans in vivo and in vitro. Mice were classified into three groups: control groups of six-week-old (YC) and eighteen-month-old mice (AC) and a group receiving 5%

Indexed as

Dental CariesGingivaAnimalsCariostatic AgentsErythritolFibroblastsHumansHydrogen PeroxideInfantMiceNF-kappa BRNA, MessengerTumor Necrosis Factor-alphaCariostatic AgentsErythritolHydrogen PeroxideNF-kappa BRNA, MessengerTumor Necrosis Factor-alphacellular senescencegingivaoral agingsenolytic drugssugar alcohol

Identifiers

PMID37764833
PMCPMC10537281
OpenAlexW4386895173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.