Evidence map›Paper›PMID 37764792›Full record

ArticleNutrients2023

Adherence to Mediterranean Diet Is Associated with Multiple Sclerosis Severity.

Monica Guglielmetti, Wahidah H Al-Qahtani, Cinzia Ferraris, Giuseppe Grosso, Simona Fiorini, Eleonora Tavazzi, Giacomo Greco, Alessandro La Malfa, Roberto Bergamaschi, Anna Tagliabue

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06715436 (The Effects of Ketogenic Diet Therapy Versus the Mediterranean Diet on Quality of Life in a Group of Patients With Multiple Sclerosis - the KETOMED-MS Study), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06715436 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effects of Ketogenic Diet Therapy Versus the Mediterranean Diet on Quality of Life in a Group of Patients With Multiple Sclerosis - the KETOMED-MS Study

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2024 to 2025Enrolled111ConditionsMultiple Sclerosis, Relapsing-RemittingArmsMediterranean Diet, Ketogenic Diet, Control group
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monica GuglielmettiHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Wahidah H Al-QahtaniDepartment of Food Sciences & Nutrition, College of Food & Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Cinzia FerrarisHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-4148-2136
Giuseppe GrossoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3930-5285
Simona FioriniHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Eleonora TavazziIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-2580-3646
Giacomo GrecoIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0001-8097-0565
Alessandro La MalfaIRCCS Mondino Foundation, 27100 Pavia, Italy.
Roberto BergamaschiIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-1397-511X
Anna TagliabueHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-7647-6975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently available data suggest that the union of a balanced diet and an overall healthy lifestyle may determine an amelioration in several clinical parameters and in the quality of life for patients with MS (pwMS). The study objective was to investigate the possible difference in MS severity in a group of Italian patients with MS based on their adherence to Mediterranean Diet (MedDiet). Eating habits were collected through a validated 110-items Food Frequency Questionnaire, the Medi-Lite score was used for adherence to MedDiet evaluation. MS severity was graded according to Herbert's severity scale, based on the MSSS. 106 patients were classified in 3 groups according to their MedDiet adherence (low/medium/high). Higher adherence was associated with a 6.18 (95% CI: 1.44, 26.59) higher probability of having a mild-to-moderate MS. When studying the single constituents of the Medi-Lite score, none of them was individually associated with MS severity. It remains unclear whether effects of specific dietary components included in the MedDiet may impact the health status at disease onset or can slow down the symptoms due course of disease. Future studies are needed to reproduce our findings and should focus on answering the latter raised question.

Indexed as

Diet, MediterraneanMultiple SclerosisHealth StatusHealthy LifestyleHumansQuality of Lifedietary habitsMediterranean dietmultiple sclerosismultiple sclerosis severity

Identifiers

PMID37764792
PMCPMC10537892

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.