Evidence map›Paper›PMID 37764709›Full record

ArticleNutrients2023

Uncovering Predictive Factors and Interventions for Restoring Microecological Diversity after Antibiotic Disturbance.

Jing Chen, Jinlin Zhu, Wenwei Lu, Hongchao Wang, Mingluo Pan, Peijun Tian, Jianxin Zhao, Hao Zhang, Wei Chen

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing ChenState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.ORCID 0009-0001-7089-2572
Jinlin ZhuState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-4296-5914
Wenwei LuState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Hongchao WangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.ORCID 0000-0001-7148-7555
Mingluo PanState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Peijun TianState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Hao ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Wei ChenState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.

Funding

Jianxin Zhao No. 31972085Jinlin Zhu JUSRP622034Wei Chen No. 32021005, No. 31820103010
6 · The paper itself

Abstract

Antibiotic treatment can lead to a loss of diversity of gut microbiota and may adversely affect gut microbiota composition and host health. Previous studies have indicated that the recovery of gut microbes from antibiotic-induced disruption may be guided by specific microbial species. We expect to predict recovery or non-recovery using these crucial species or other indices after antibiotic treatment only when the gut microbiota changes. This study focused on this prediction problem using a novel ensemble learning framework to identify a set of common and reasonably predictive recovery-associated bacterial species (p-RABs), enabling us to predict the host microbiome recovery status under broad-spectrum antibiotic treatment. Our findings also propose other predictive indicators, suggesting that higher taxonomic and functional diversity may correlate with an increased likelihood of successful recovery. Furthermore, to explore the validity of p-RABs, we performed a metabolic support analysis and identified

Indexed as

Anti-Bacterial AgentsGastrointestinal MicrobiomeMice, Inbred C57BLAkkermansiaAnimalsBacteriaBacteroidesBiodiversityFecesMaleMiceAnti-Bacterial AgentsAkkermansia muciniphilaantibiotic disturbancecross-cohort analysisensemble learning frameworkgut microbiomepredictive recovery-associated bacterial species (p-RABs)

Identifiers

PMID37764709
PMCPMC10536327

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.